Daforin: Uses, Contraindications, Risks, Interactions, Dosage, Adverse Reactions and Overdose

It is intended for the treatment of depression associated or not with anxiety, bulimia nervosa, and obsessive-compulsive disorder (OCD) (anxiety characterized by obsessive thoughts).

It is also used to treat the premenstrual dysphoric disorder (PMDD), including premenstrual tension (PMT), irritability, and dysphoria (sudden and fleeting change in mood such as feelings of sadness, grief, distress).

Contraindications and risks of Daforin

Darin is contraindicated for patients allergic to fluoxetine or any of the formula’s components.

It was also contraindicated for patients using other MAOIs (another class of antidepressants), reversible or not, such as tranylcypromine sulfate, pure or in combination, and moclobemide.

This contraindication remains until at least 14 days after stopping treatment with an MAOI from starting treatment with Daforin.

The combination of Daforin with thioridazine is contraindicated due to the risk of serious adverse effects, which can be fatal.

This medicine is contraindicated if the patient is treated with pimozide. If you are using any of these medicines, the doctor should be informed, as the treatment must be stopped before starting treatment with Daforin.


Darin is not indicated for children or adolescents.

Drug interactions

As with other medicines used to treat depression, Daforin should be administered with care to patients with a history of seizures.

If you need to stop taking Daforin, consult your doctor first, as other symptoms may arise when you stop taking it suddenly.

Antidepressants are medicines used to treat depression and other illnesses. Patients and their family members or other caregivers should discuss all treatment options with their healthcare professional, not just the use of antidepressants. And the risks of trying or not with this type of medication.

In patients with diabetes, hypoglycemia (low blood sugar) occurs during treatment and hyperglycemia (high blood sugar) after discontinuation of the drug.

In this case, the dose of insulins or another medicine to treat this condition must be adjusted for the duration of the treatment with Daforin and after the end of use.

No differences were observed in the safety and efficacy of fluoxetine hydrochloride in elderly and young patients. Although the elderly could be more sensitive.

Darin should not be administered to children because efficacy and safety have not been established.

The possibility of a suicide attempt is characteristic of a depressive picture.

As with other antidepressants, isolated cases of suicidal ideation (idea formation) and behaviors have been reported during fluoxetine treatment or shortly after treatment discontinuation.

Skin rash, anaphylactic reactions (severe allergic reactions), and progressive systemic reactions, sometimes powerful and involving skin, liver, kidneys, and lungs, can occur in patients treated with fluoxetine.

If a skin rash occurs, inform the doctor immediately.

Hyponatremia (low sodium in the blood) has been reported in most elderly patients or patients using diuretics (e.g., furosemide, hydrochlorothiazide).

While Daforin is administered, do not drive or operate machinery.

Drug Interactions – Drug Daforin

It should be administered with caution in patients taking the following medications: Medications metabolized by the liver (e.g., chlorpromazine, propranolol, propafenone, paracetamol).

Medications active in the central nervous system can be modified in blood levels.

Drugs that bind to plasma proteins (for example, acetylsalicylic acid, phenytoin, diclofenac, and diazepam) can cause a change in the plasma concentration of Daforin®.

  • Warfarin: Altered anticoagulant effects (laboratory values ​​and clinical signs and symptoms) may occur, including bleeding, without a consistent pattern; they have been reported infrequently when fluoxetine and warfarin were administered concomitantly.
  • Thioridazine: There is a risk of serious adverse events such as cardiac arrhythmias, which can be fatal when administered with fluoxetine.

Drug-Treatment Interaction

Electroconvulsive treatment: there are reports of prolonged seizures in patients using fluoxetine and receiving electroconvulsive therapy.

Drug – Chemical Substance Interactions


In formal tests, fluoxetine was not found to increase blood levels of alcohol or potentiate the effects of alcohol. However, the combination of alcohol with Daforin treatment is not advisable.

Drug Interactions – Medicinal Plant

Hypericum perforatum (St. John’s Wort)

Pharmacodynamic interactions can occur between fluoxetine and the St. John’s wort (Hypericum perforatum) plant-based product, resulting in increased undesirable effects.

Use in pregnancy and lactation.

As with other medicines used to treat depression, Daforin should be administered with care to patients with a history of seizures.

Fluoxetine is excreted in human milk. Therefore, breastfeeding women should inform their doctors before starting treatment with Daforin.

There was no evidence of carcinogenicity (ability to induce cancer) or mutagenesis (ability to induce mutations) from in vitro or animal studies.

Caution should be exercised using fluoxetine during pregnancy, particularly in late pregnancy, when transient withdrawal symptoms (for example, transient tremors, feeding difficulties, tachypnea (rapid breathing), and irritability) are newly born after the use of the drug close to term.

Fluoxetine can be administered during pregnancy if the benefits of treatment justify this drug’s potential risk.

The use of fluoxetine after the 20th week of gestation may be associated with an increased risk of persistent pulmonary hypertension in the newborn.

Darin should not be used by pregnant women unless indicated by the doctor.

To avoid danger to your health, inform about the treatment with Daforin.

Dosage, dosage, and instructions for the use of Daforin


The recommended starting dose is 20 mg/day (2 capsules of 10 mg or one tablet of 20 mg).

Bulimia nervosa

The recommended dose is 60 mg / day (6 capsules of 10 mg or three tablets of 20 mg).

Obsessive-compulsive disorder (OCD)

The recommended dose is 20mg to 60mg / day (2 to 6 10mg capsules or 1 to 3 20mg tablets).

Premenstrual Dysphoric Disorder (PMDD -TPM)

The recommended dose is 20 mg / day (2 capsules of 10 mg or one tablet of 20 mg) administered continuously (on all days of the menstrual cycle) or intermittently (i.e., daily use, starting 14 days before the planned start of menstruation, until the first day of menstrual flow, the dose will be repeated with each new menstrual cycle).

Respect the schedules, doses, and duration of treatment. Do not stop the treatment without the doctor’s prior knowledge.

This medicine should not be split, opened, or chewed.

Adverse reactions

The following side effects (ills) have been reported with the use of fluoxetine hydrochloride:

Common reactions

Reactions that occur in 1% to 10% of patients using this drug may include:

  • Anxiety.
  • Diarrhea.
  • Drowsiness.
  • General weakness
  • Headache.
  • Hyperhidrosis (excess sweating).
  • Insomnia.
  • Sickness.
  • Nervousness.
  • Yawn.

Unusual reaction

These occur between 0.1% and 1% of patients using this medicine.

They may include:

  • Crampy abdominal (tummy) pain.
  • Decreased sexual desire
  • Sexual impotence
  • A prolonged erection (priapism).
  • Hair loss.
  • Chest pain (chest pain).
  • Chills (tremors)
  • To.
  • Constipation.
  • Dizziness.
  • Lack or loss of appetite.
  • Fatigue (tiredness)
  • Alteration of concentration or reasoning.
  • Nasal congestion.
  • Itching of the skin (itching).
  • Buzz.
  • Threw up.
  • Weightloss.
  • It increased urinary frequency.
  • Mialgia (muscular pain).
  • Arthralgia (joint pain).
  • Tachyarrhythmia (rapid heartbeat).
  • Fever.
  • Flatulence (gas).
  • Abnormal vision (cloudy, enlarged pupil).
  • Menstrual cramping dysmenorrhea).
  • Dyspnea (shortness of breath)
  • Urticaria (skin allergy).
  • Xerostomia (dry mouth).
  • Photosensitivity of the skin (increased skin sensitivity to the sun).

Rare reactions

They can occur between 0.01% and 0.1% of patients using this medicine.

These reactions include:

  • Abnormal liver (liver) function.
  • Allergic reactions.
  • Drug hepatitis (caused by the drug).
  • Flu symptoms, symptoms of hypoglycemia (low blood glucose).
  • Increased risk of bleeding.
  • Lymphadenopathy (growth of lymph nodes).
  • Humor changes.
  • Weight gain.
  • Suicidal ideas and behaviors.

Frequently unknown reactions

They include:

  • Autonomic symptoms (including dry mouth, sweating, vasodilation, chills).
  • Hypersensitivity (including itching, skin rash, hives, anaphylactoid reaction, vasculitis, serum sickness-like reaction, angioedema).
  • Dysphagia.
  • Dyspepsia (indigestion).
  • Alteration of the palate.
  • Ecchymosis (reddish spots).
  • Tremor / abnormal movement (including contraction, ataxia, oro-glossal syndrome, myoclonus, earthquake).
  • Anorexia (including weight loss).
  • Palpitation.
  • Psychomotor restlessness.
  • Vertigo.
  • Manic reaction.
  • Sleep disorders (including abnormal dreams).
  • Seizures

Inform your doctor, dental surgeon, or pharmacist of the appearance of undesirable reactions due to the use of the medicine. Also, inform the company through their helpdesk.

Darin overdose

In this case, the symptoms that can occur are:

  • Sickness.
  • Vomiting
  • Seizures
  • Cardiovascular dysfunction (variation of the heart rate until cardiac arrest).
  • Pulmonary dysfunction
  • Signs of alteration of the Central Nervous System -SNC (varying from excitement to coma).

Cases of death have been sporadic.

In case of overdose with Daforin, check the patient’s breathing and heartbeat conditions and keep it quickly to a place of medical attention.

In case of using a large quantity of this medicine, seek prompt medical attention and take the medicine package or leaflet with you.

In case of overdose with Daforin, check the patient’s breathing and heartbeat conditions and quickly transfer him to a place of medical attention.