Index
It is the association of pro inox hydrochloride and lysine clonixinate.
Compound serial is an analgesic and antispasmodic drug indicated to treat pain and spasm of smooth muscle located in any part of the digestive, genital, urinary, and hepatolenticular tracts.
Presentation of composite serial
This medicine has:
- An oral presentation: coated tablets.
- An intramuscular or intravenous indication: injectable solution.
The active substance in the compound serial is propinox (pargeverine) and lysine clonixinate.
Compound serial dosage
Typical dosages are generally:
Adults and children over 12 years: 1 coated tablet 3 to 4 times a day. The coated tablets should be swallowed whole, without chewing, and plenty of fluids.
This medicine must be administered under the strict prescription of the doctor. Don’t self-medicate.
Compound signal interactions
The following are just a few interactions, so these are not all drugs that interact with the compound serial.
- Alcohol: The use of alcohol after ingestion of ibuprofen may increase the risk of an additive effect of upper gastrointestinal bleeding in damaging the gastric mucosa. Avoid drinking alcohol within 12 hours of taking this drug.
- Alendronate: The use of alendronate may increase the gastrointestinal adverse effects of ibuprofen.
- Aminoglycosides: concomitant use can increase the nephrotoxic effects of aminoglycosides, and NSAIDs can reduce their renal excretion. It is suggested to monitor renal function during co-administration.
- Oral anticoagulants: The use of oral anticoagulants may increase the risk of bleeding due to the displacement of protein-binding anticoagulants.
- Aspirin: The use of ibuprofen with aspirin may decrease the latter’s effectiveness for platelet aggregation due to competition for the binding of the cyclooxygenase site.
- Cyclosporine: the use of an NSAID with cyclosporine may increase the concentrations of the latter and increase the risk of renal toxicity. Measure cyclosporine in the blood and monitor kidney function and adjust the dose.
- Clopidogrel: Concurrent administration with clopidogrel may increase the risk of gastrointestinal bleeding due to the antiplatelet effect of the latter. Look for signs or symptoms of gastrointestinal bleeding.
- Levofloxacin: The use of an NSAID and levofloxacin may increase the risk of seizures in patients with a history of epilepsy or outbreaks by inhibiting the action of gamma-aminobutyric acid (GABA) centrally.
- Pemetrexed: Concomitant use of these drugs increases the toxicity of pemetrexed (myelosuppression, nephrotoxicity, gastrointestinal toxicity), and NSAIDs interfere with renal excretion.
- Sulfonylureas: The use of sulfonylureas with an NSAID may increase the risk of hypoglycemia, possibly due to inhibition of metabolism and protein binding competition. This effect is seen more often with first-generation sulfonylureas (chlorpropamide, tolbutamide, glibenclamide).
- Tacrine: the use of NSAIDs can increase the hepatotoxic effect of tacrine. Avoid association; otherwise, monitor liver function during combination therapy.
- Tacrolimus: The use of an NSAID with tacrolimus can lead to renal failure, probably by inhibiting the production of renal vasodilator prostaglandins. Avoid this association or do not control kidney function.
- Valerian: joint use increases the risk of hepatotoxicity. Avoid co-administration; otherwise, monitor liver function.
Side effects of compound serial
The following are some effects derived from the use of Compound Serial:
- Arterial insufficiency generally of the Raynaud’s type, bradycardia, CHF, edema, hypotension, and intensification of AV block.
- Dizziness
- Fatigue.
- Alopecia.
- Erythema multiforme.
- Exfoliative dermatitis.
- Psoriasiform eruptions.
- Stevens-Johnson syndrome.
- Toxic epidermal necrolysis.
- Urticaria.
- Dry eyes, visual disturbances.
- Abdominal cramps, constipation, diarrhea, epigastric distress, ischemic colitis.
- Trombosis arterial mesentérica.
- Sickness.
- Vomiting
- Impotence.
- Agranulocytosis, non-thrombocytopenic and thrombocytopenic purpura.
- Hypersensitivity
- Agranulocytosis, anaphylactic / anaphylactoid reactions,
- Fever combined with malaise and sore throat, laryngospasm, pharyngitis, and respiratory distress.
- Bronchospasm, shortness of breath, dyspnea, wheezing.
- Peyronie’s disease, SLE-like reactions, systemic lupus erythematosus.
Side effects may vary depending on the condition and other factors inherent to the patient, such as:
age, health, or other underlying diseases.
Contraindications
Compound serial is contraindicated in the following cases:
- It should not be administered during pregnancy and lactation.
- It is contraindicated in patients with peptic ulcers or gastrointestinal bleeding.
- Use with caution in cases of coronary artery disease, peripheral vascular disease, severe hypertension, and liver or kidney failure.
