Ceftazidime: Uses, Dosage, Interactions, Pregnancy, Lactation and Side Effects

It is a drug from the group of third generation cephalosporinantibiotics and is designed for parenteral use only.

It has demonstrated activity against Gram-positive and Gram-negative aerobic bacteria, especially against enterococci, including strains that produce beta-lactamase.

Other names of ceftazidime: Fortaz, Tazicef.

Uses of this medicine

Ceftazidime is used to treat the following infections:

  • Meningitis bacterial.
  • Nosocomial pneumonia .
  • Complicated infection of soft tissues.
  • Complicated urinary tract infections.
  • Complicated intra-abdominal infections.

Ceftazidime can be applied as a perioperative prophylaxis of urinary tract infections in patients undergoing transurethral resection of the prostate .

This medication should not be used in patients with a known allergy to cephalosporinor penicillin antibiotics .

Ceftazidime is excreted by the kidneys, and patients who have kidney failure should use a reduced dose. It must be administered carefully in combination with other drugs that have known nephrotoxic potential (for example, gentamicin ).

It should not be applied more than recommended by your doctor, as it can lead to an overgrowth of the microorganism that can develop a certain mechanism of resistance to ceftazidime.

Pregnancy and lactation

There are limited data for the use of ceftazidime in pregnant women.

Classification of the FDA as Group B: studies in animals have not shown direct adverse effects with respect to embryonic, fetal and postnatal development.

According to the American Academy of Pediatrics, ceftazidime is safe to use during breastfeeding. It is excreted in breast milk in small amounts, but it is expected that a therapeutic dose of this medicine has no effect on babies.

Dosage

The recommended dose for adults and children weighing more than 40 kg are given below:

  • Bronchopulmonary infection that accompanies cystic fibrosis: 100-150 mg / kg body weight, divided into three equal doses. The maximum daily dose is 9 grams.
  • Complicated infection of the urinary tract: 1-2 g three to four times a day.
  • Complicated soft tissue infections: 1-2 g three times a day.
  • Complicated intra-abdominal infections: 1-2 g three times a day.
  • Complicated skin infections: 1-2 g three times a day.
  • Perioperative prophylaxis of infections in transurethral resection of the prostate: 1 g during the induction of anesthesia and 1 g during catheter removal.

This medicine can be administered only in a healthcare setting.

Interactions

Like all other antibiotics, ceftazidime should not be given simultaneously with vaccines because it can reduce its effectiveness.

Ceftazidime enters into moderate interactions with the following medications

Oral contraceptives such as:

  • Etinilestradiol, levonorgestrel, desogestrel y etinil estradiol / noretindrona.

Ceftazidime reduces the effectiveness of these medications, so it is recommended to use an alternative method of contraception during treatment with ceftazidime.

Other nephrotoxic antibiotics, such as:

  • Tobramycin, amikacin and gentamicin.

Hand diuretics:

  • Furosemide and torasemide, which are also known for their nephrotoxic potential.

Side effects

If you have one or more effects after the administration of this medicine, call your doctor or go to a health center closest to your home.

Ceftazidime may cause the following side effects

  • Higher than normal level of eosinophils in the blood (also called eosinophilia).
  • Greater amount of platelets in the blood (also called thrombocytosis ).
  • Candidiasis (which can affect the oral cavity and the vaginal mucous membrane).
  • Decrease in the number of platelets in the blood (also called thrombocytopenia ).
  • Decrease in the number of leukocytes in the blood (also called leukopenia ).
  • Hemolytic anemia.
  • Erythema multiforme.
  • Diarrhea.
  • Weep.
  • Acute renal failure.
  • Interstitial nephritis
  • Allergy.
  • Fever.
  • Sore throat.
  • Swelling in the face or tongue.
  • Burning eyes.
  • Pain in the skin
  • Difficult breathing
Less serious side effects may include
  • Sickness.
  • Vomiting
  • Stomach ache.
  • Headache.
  • Dizziness
  • Numbness or tingling sensation
  • Itching .
  • Vaginal discharge

This is not a complete list of side effects and others may occur. Call your doctor for medical information about side effects.

To make sure you can use ceftazidime safely, tell your doctor if you have any of these other conditions:

  • Kidney disease
  • Liver disease
  • Stomach or intestinal disorder such as colitis .
  • Diabetes.
  • Congestive heart failure.
  • Penicillin allergy.
  • Cancer.
  • Malnourishment .
  • If you have had a very recent surgery or medical emergency.

If you have doubts or questions about your health, you should always consult a doctor or other health professional.