Cefoxitin: Uses, Administration, Side Effects and Warnings

It is an antibiotic that belongs to rifamycins, which are molecules produced by the bacterium Streptomyces lactamdurans.

These belong to the group of second-generation cephalosporins.

In general, Cefoxitin and second-generation cephalosporins are characterized by having a broad spectrum of action that is effective in both Gram-positive and Gram-negative bacteria. They also have pharmacokinetic properties.

Cefoxitin acts by inhibiting bacterial wall synthesis from the molecular point of view. Like other cephalosporins, this antibiotic can bind to the transpeptidase enzymes that create the bonds between the chains of peptidoglycans (the polymers essential for the formation of the bacterial wall).

In turn, the activity of transpeptidase enzymes inhibits the stability of the bacterial cell wall, resulting in the death of growing bacterial cells.

The activity spectrum of Cefoxitin is quite similar to that of Cefamandol. It is less effective than first-generation cephalosporins and leans towards Gram-positive bacteria; however, it is very effective against anaerobic bacteria.


Cefoxitin is used to treat infections by anaerobic bacteria or mixed anaerobic, aerobic conditions. It is also used to treat intra-abdominal infections (for example, appendicitis: inflammation of the appendix ) and certain infections of the female genital tract.


It is most effective against infections caused by Gram-negative bacteria resistant to antibiotic therapy and the possible cause of more severe diseases.


Cefoxitin is administered parenterally as a sodium salt (in the form of a powder and solvent solution to be injected intramuscularly or intravenously).

Side effects

The primary treatment with Cefoxitin is generally well tolerated. The most common side effects that are seen, especially in susceptible individuals, include the following:

  • Gastrointestinal disorders: nausea, vomiting, diarrhea, abdominal pain.
  • Abnormalities of renal function: glomerular and tubular damage, urinary anomalies, proteinuria.
  • Abnormalities of liver function: increased transaminases; increase in bilirubin.
  • Hematological abnormalities: hemolytic anemialeukopenianeutropenia.
  • Neurological symptoms: lethargy, spasms.
  • Allergic reactions: itching, urticariaangioedemabronchospasmhypotension, anaphylactic reactions.

Obtain emergency medical assistance with these sensitivity indicators: nettle rash, labored breathing, mouth, and tongue.

Call an expert doctor immediately if you have any of these essential adverse reactions:

  • Vomiting, sore throat, and headache with severe blistering and cracking, crimson pores, and rapid skin.
  • Swelling.
  • Rash, discoloration, extreme tingling, apathy, pain, weakness of muscle tissue.
  • Fainting.
  • Bruising without effort or maybe internal bleeding is a rare weakness.
  • Temperature, chills, physical discomfort, signs or symptoms of influenza virus.
  • Urinating much less than usual or in any other way.


Avoid using this medication if you are allergic to Cefoxitin or comparable medicines, such as Ceftin, Cefzil, Keflex, and Omnicef, among others.

Before using this medication with a prescription, tell your doctor if you are allergic to any medicine (specifical penicillin).

Also, tell your doctor if you have a kidney disorder, type 2 diabetes, heart failure, most cancers, intestinal tract dysfunction, or maybe if you are malnourished.

Bring this medication for the entire time approved by your doctor. The signs and symptoms of a person may be higher before the disease is treated. Cefoxitin probably will not treat the infection of the virus, such as the common cold and the flu virus.

Medications with antibiotics cause diarrhea, which is often an indication of a new disease.

Medicines could make you have strange final results by having specific medical tests, such as tests to control sugar and carbohydrates.