Butylhyoscine Metamizole Sodium: Indications, Contraindications, Precautions, Interactions, Administration and Undesired Effects

Buscopan compositum (by its commercial name) is used in the case of motility, stomach and intestinal disorders, and urinary and biliary tract.

Indications

Buscopan compositum is indicated in adults and children over ten years of age in cases of:

Pain and spasms in the stomach and intestines.
Pain due to obstacles in the flow of the urinary tract and bile ducts (where bile flows, a substance involved in some digestive processes).
Period pains.

Talk to your doctor if you don’t feel better or worse after three days.

Contraindications

When buying hyoscine, metamizole sodium should not be used.

Do not take butylhyoscine metamizole sodium:

If you are allergic to the components of the medicine or NSAIDs (non-steroidal anti-inflammatory drugs, medications for pain and inflammation) or any of the other ingredients of this medicine.
If you suffer from acute angle glaucoma (a severe form of glaucoma, an eye disease caused by an increase in the pressure of the fluid contained within the eye).
If you suffer from prostatic hypertrophy (enlargement of the prostate).
If you suffer from urinary retention (inability of the urinary bladder to empty).
If you suffer from pyloric stenosis (narrowing of the pylorus, the terminal portion of the stomach) or stenosis of other routes of the gastrointestinal tract (narrowing of different areas of the stomach and intestine).
If you suffer from diseases of the intestine associated with bowel disorders, such as paralytic ileus (intestinal obstruction), ulcerative colitis (chronic inflammatory bowel disease), and megacolon (colon dilation).
If you suffer from reflux esophagitis (a disorder caused by frequent regurgitation of stomach contents into the esophagus, the tube that carries food to the stomach).
If you are elderly or your physical condition is weak, you suffer from intestinal atony (lack of bowel movements that cause an intestinal obstruction).
If you suffer from myasthenia gravis (muscle weakness).

In case of fewer than ten years

If your body does not make an enzyme called glucose -6-phosphate dehydrogenase (a disease known as favism, which destroys some red blood cells, the red blood cells).
If you suffer from severe hemolytic anemia (infection due to the destruction of red blood cells).
If you have severe hepatocellular insufficiency (impaired liver function associated with the destruction of liver cells).
In case of rare hereditary conditions that may be incompatible with an excipient of the product.

Usage precautions

What you need to know before taking Buscopan Compositum

Talk to your doctor or pharmacist before taking this medicine.

Contact your doctor immediately if you experience severe pain in the belly area, which does not pass or worsens or is accompanied by symptoms such as:

Fever.
Sickness.
Vomiting
Changes in bowel movements.
Swelling of the belly
It decreased blood pressure.
Fainting.
Blood in the stool.

To avoid an overdose of paracetamol, one of the active ingredients in buscopan compositum, you have to make sure that you do not take other medicines containing acetaminophen or paracetamol at the same time because if paracetamol is taken in high doses, it can cause serious side effects.

Do not exceed the recommended doses as it can cause liver damage.

Buscopan compositum should be used with caution:

If your body produces insufficient amounts of glucose-6-phosphate dehydrogenase (a disease known as favism, which destroys red blood cells).
If you suffer from liver diseases such as hepatitis (inflammation of the liver), Gilbert’s syndrome (a disorder characterized by an excessive increase in bilirubin in the blood, from mild to moderate). Hepatocellular failure (impaired liver function associated with the destruction of liver cells).
If you regularly use large amounts of alcohol.
If your kidneys are not working well.
If you are subject to angle-closure glaucoma (a severe form of glaucoma, an eye disease caused by an increase in the pressure of the fluid contained within the eye).
If you are predisposed to intestinal or urinary tract obstructions.
If you are predisposed to tachycardia (increased frequency of the heartbeat).
If you have high blood pressure.
If you have congestive heart failure (heart disease).
If you are subject to hyperthyroidism (exaggerated functional activity of the thyroid, with the presence in the circulation of many thyroid hormones).
If you suffer from chronic obstructive airways.

Buscopan compositum should only be used under medical supervision:

If you suffer from kidney failure ( severe kidney disease).
If you suffer from impaired liver function (severe liver disease).
Under these conditions, if necessary, your doctor will decrease your dose or extend the interval between respective administrations.
Suppose you need to take buscopan compositum for a long time. In that case, you will also need to carry out the necessary tests to check the blood values and the functionality of your kidneys and liver, as determined by your doctor.
If you often use pain relievers (pain relievers), especially in high doses, you may experience headaches. In this case, the amount of pain reliever should not be increased to treat it.
If, after taking butylhioscine metamizole sodium, you have allergic reactions, you should stop treatment as soon as possible as signs of an allergic reaction and contact your doctor immediately.

Do not take butylhyoscine metamizole sodium for more than three days unless your doctor tells you otherwise.

If the pain does not go away or worsens, if you experience new symptoms, or if you have redness or swelling, see your doctor, as these may be symptoms of a severe illness. Also, consult your doctor before taking any other medications.

Interactions

Tell your doctor or pharmacist if you are using, have recently used, or might take any other medicines. In particular, use this drug with caution and only under strict medical supervision in the following situations:

If you take regular medications or substances that put an excessive workload on the liver.

Some examples of these medications are:

Rifampicin (an antibiotic)
Cimetidine (a medicine used in cases of stomach ulcers).
Antiepileptics (drugs used to treat people such as glutethimide, phenobarbital, and carbamazepine).

This also applies to all substances that can be harmful to the liver.

If you are taking chloramphenicol (to treat infections), such as buscopan compositum can delay the removal of chloramphenicol from your body, creating a harmful effect on your body.
If you need to take buscopan for a long time and take anticoagulants simultaneously (medicines to thin the blood, for example, warfarin and coumarin derivatives).
If you are taking zidovudine (AZT or Retrovir, a medicine to treat HIV) because you may have a reduction in the number of blood cells and white blood cells.
If you are taking probenecid (a medicine used to treat gout, for example), a reduction in the dose of paracetamol may be necessary.
If you are taking cholestyramine (to lower cholesterol), it reduces the absorption of paracetamol.

Other types of medications:

Tri and tetracyclic antidepressants.
Antipsychotics (medicines used for mental disorders).
Quinidine (heart medicine).
Amantadine (medicines for diseases of the central nervous system that involve a loss of control of movements, such as Parkinson’s disease).
Disopyramide (heart medicine) and other drugs such as tiotropium and ipratropium (used for respiratory diseases).
Substances are similar to atropine (a substance that acts at the nervous system level) because its effect can be increased by Buscapina compositum.
If you are taking medicines for vomiting and nausea, such as metoclopramide, both its effect and buscopan compositum may decrease.
If you take beta-adrenergic, Buscopan compositum can increase the tachycardia (increased heart rate) induced by these medicines.

Medicines that delay stomach emptying (such as propantheline, a treatment for stomach ulcers) can slow the absorption of acetaminophen while waiting for its effect.

In contrast, medications that increase the rate of stomach emptying (such as metoclopramide, a drug against vomiting and nausea) increase the absorption rate of paracetamol.

Laboratory exams

Paracetamol, one of the active substances in buy hyoscine metamizole sodium, can alter the results of some laboratory tests, for example, the determination of »serum uric acid (the amount of uric acid in the blood) and blood glucose (sugar in the blood).

Tell your doctor or laboratory personnel that you are taking butylhyoscine metamizole sodium if you need to have blood tests.

Alcohol

If you regularly consume large amounts of alcohol, you should buy hyoscine metamizole sodium with extreme caution. Otherwise, you could damage your liver.

Pregnancy, breastfeeding, and fertility

If you are pregnant, think you may be pregnant or are planning to become pregnant, or if you are breastfeedingbreastfeeding, consult your doctor or pharmacist before using this medicine.

Pregnancy

There are no adequate data on the use of buscopan compositum during pregnancy. The available information resulting from this medicine indicated insufficient evidence of undesirable effects during pregnancy in women.

During pregnancy, the data obtained in the case of excessive doses of paracetamol did not show an increased risk of malformations or harmful effects.

During pregnancy, paracetamol should not be taken for long periods, in high doses, or combined with other medications, as the safety of using the drug in these cases has not been established.

Therefore, buscopan compositum is not recommended during pregnancy and can only be taken after consulting your doctor.

Lactation

The safety of using the drug while breastfeedingbreastfeeding has not yet been established. Paracetamol passes into breast milk. However, it is expected that at average doses, it will not cause unwanted effects in the newborn.

The decision to continue or discontinue breastfeedingbreastfeeding or to continue or discontinue treatment with Buscopan should only be made after consulting your doctor.

Fertility

No studies have been performed on the effects on fertility in humans.

This medicine contains 4.32 mg of sodium per tablet. To take into account patients on a controlled sodium diet.

Driving and using machines

No studies have been performed on the ability to drive and use machines. However, visual disturbances and drowsiness can occur; consider them if you go in vehicles or machinery or perform jobs that require attention and vigilance.

Dosage, mode, and time of administration

How to use butylhyoscine metamizole sodium:

Posology

Follow exactly the instructions of administration of this leaflet described in this leaflet or as directed by your doctor or pharmacist. If you are not sure, talk to your doctor or pharmacist.

The following dosage is recommended for adults and children over ten years of age unless otherwise noted:

The recommended dose is 1-2 tablets three times a day. Do not exceed six tablets per day. The tablets should not be chewed but instead swallowed whole with a sufficient amount of water.

Treatment duration

Do not take buscopan compositum for more than 3 days unless your doctor tells you to.

Consult your doctor if you are taking other medicines containing paracetamol simultaneously, as your dose may need to be changed.

Use in children

Butylhyoscine metamizole sodium should not be used in children under ten.

Overdose

What to do if you have taken too much butylhyoscine metamizole sodium

Tell your doctor immediately or contact the nearest hospital if you take too much of this compound.

If you take too much acetaminophen, older people, young children, people with liver problems, those who regularly consume alcohol, or those who are malnourished are at higher risk of poisoning, even with a fatal outcome.

Symptoms in case of overdose

If an excessive dose was taken, effects such as:

Urinary retention (difficulty of the urinary bladder to empty).
Dry mouth
Redness of the skin.
Tachycardia.
Reduction of intestinal and stomach motility.
Transitory visual disturbances.

Paracetamol overdose

Symptoms usually appear within the first 24 hours and include:

Pallor.
Sickness.
Vomiting
Anorexia (lack of appetite).
Pain in the abdomen (the area of abdominal pain).

You may have a transient improvement in these symptoms, but mild abdominal pain may persist, which may still be a sign of liver damage.

There may be an increase in blood transaminases (substances in the liver).
Jaundice (manifested by yellowing the skin or the whites of the eyes).
Blood clotting disorders (disorders that affect the flow of blood).
Hypoglycemia (low amounts of sugar in the blood).
The transition to a hepatic coma (severe liver damage associated with brain disorders, that is, covering the brain).

If you take too much acetaminophen, there is a risk of severe liver damage, leading to coma and death. Liver damage should be evaluated by the doctor who will prescribe the necessary tests to assess your liver function.

If you take an overdose of paracetamol, you can also develop kidney damage and disorders of the heart and pancreas (the gland involved in the digestion and transformation of some nutrients).

Chronic intoxication

In cases of chronic poisoning, it can produce:

Hemolytic anemia (a disease caused by the destruction of specific blood cells, the red blood cells).
Cyanosis (a state in which the skin turns blue).
Soft spot.
Dizziness.
Paresthesia (a condition that occurs mainly with tingling in the arms or legs).
Tremors
Insomnia.
Headache (headache), memory loss, central nervous system disorders.
Delirium (a state of mental confusion) and seizures (involuntary contraction of one or more muscles).

If you have taken too much of this medication, contact your doctor immediately or your nearest hospital. The doctor will prescribe the appropriate therapy.

If you forget to take buscopan compositum

Do not take a double dose to make up for a forgotten dose.

If the combination of deja de usar buscapina

If you suddenly stop taking painkillers (pain relievers) after using them for an extended period in high doses, you may experience symptoms such as:

Headaches.
Fatigue.
Nervousness.

These symptoms generally disappear within a few days. Before retaking pain relievers, see your doctor and wait until these symptoms have passed. If you have any further concerns or questions about the use of this medicine, ask your doctor or pharmacist.

Unwanted effects

What are the side effects of buscopan compositum?

This medicine can have side effects like all medicines, although not everyone gets them. Possible side effects are listed below according to the following frequency:

Uncommon (may affect up to 1 in 100 people):

Skin reactions (redness of the skin).
Abnormal sweating
Itching.
Nausea.
Dry mouth.

Rare (may affect up to 1 in 1,000 people):

Shock (decrease in blood pressure with a severe reduction in heart function).
Tachycardia (increased heart rate).
Erythema (skin irritation).

Very rare (may affect up to 1 in 10,000 people):

Stevens-Johnson syndrome and epidermal necrolysis (severe skin diseases characterized by erythema, bullous lesions with areas of skin shedding).
Generalized essential pustulosis (characterized by the appearance of numerous small pustules, a burning sensation, diffuse itching, and a high fever).
Pancytopenia (reduction in the number of all types of cells in the blood).
Agranulocytosis (reducing the number of granulocytes in the blood, a type of white blood cell).
Thrombocytopenia (reduction in the number of platelets in the blood).
Leukopenia (reduction in the number of white blood cells in the blood).
Anemia (reduction of hemoglobin in the blood, a substance that carries oxygen to the blood).
Increase in blood transaminases (substances in the liver whose increase may indicate the presence of liver damage).
Reactions of various types and severity of the skin, including cases of erythema multiforme (a condition characterized by the appearance of red spots on the skin concerning the “bull’s eye” associated with itching).
Inflammation of the skin (hives, rash, rash).
Difficulty breathing.
Spasms of the bronchial muscles (especially in those who suffer from asthma or allergies).
Urinary retention (inability of the urinary bladder to empty).
Kidney disorders such as acute kidney failure (rapid reduction in kidney function), interstitial nephritis (inflammation of the kidney), hematuria (blood in the urine), and anuria (stopped or reduced urine output).
Difficulty urinating.
Perspiration.
Mydriasis (dilation of the pupil).
Visual disturbances (alteration of accommodation, that is, difficulty in focusing images, increased ocular tone, increased pressure of the internal fluid of the eye).
Constipation.
Numbness
Dizziness.

Talk to your doctor or pharmacist if you experience any side effects, including those not listed in this leaflet.

Expiration and conservation

Store at temperatures below 25 ° C.
Keep the medicine out of sight and reach of children.
Do not use this medicine after the expiration date stated on the carton after expiration.
Do not dispose of any medicine through sewage or household waste. Ask your pharmacist how to dispose of medications you no longer use. This will help protect the environment.