Butylscopolamine: Common Uses, Properties, Administration, Precautions, Side Effects and Warnings

It belongs to a group of drugs classified as antispasmodics.

Common uses

It is indicated to relieve abdominal pain or discomfort associated with transient and moderate spasms of the gastrointestinal tract.

Butylscopolamine exerts a spasmolytic action on the smooth muscles of the gastrointestinal tract; that is, it relaxes the gastrointestinal muscle when contracted in a non-physiological way ( spasm ), causing relief of abdominal pain.

Butylscopolamine Properties


Relief of abdominal pain or discomfort associated with transient and moderate gastrointestinal tract spasms.

CFT classification


Mechanism of action

N-butyl-hyoscine bromide does not pass as a quaternary ammonium derivative into the central nervous system.

Consequently, there are no anticholinergic adverse effects on the central nervous system.


The peripheral anticholinergic action results from the blocking action of the ganglia in the visceral wall, as well as from the antimuscarinic activity.

Targeted dosage

The usual dose for adults and children over six years of age is as follows:

  • 1 to 2 tablets (10 to 20 mg), 3 to 5 times a day.

Adults and adolescents over 12 years of age

  • 1 to 2 ampoules of butylscopolamine (20 to 40 mg) can be administered slowly intravenously, intramuscularly, or subcutaneously several times a day.
  • The maximum daily dose of 100 mg should not be exceeded.

Children and babies

  • In severe cases: 0.3-0.6 mg/kg, administered slowly by intravenous, intramuscular, or subcutaneous injection several times a day.
  • The maximum daily dose of 1.5 mg/kg should not be exceeded.

The usual dose for adults and children over six years of age is as follows:

  • 1 to 2 suppositories, 3 to 5 times a day.

Butylscopolamine Precautions


Do not take:

  • If you are allergic (hypersensitive) to butylscopolamine bromide.
  • If you suffer from myasthenia gravis (weakness of the voluntary muscles) or megacolon (abnormal dilation of the large intestine).
  • If you suffer from a rare hereditary disease that may be incompatible with any of the excipients of the medicine.

By intramuscular injection it is contraindicated:

  • In patients who are taking anticoagulants, an intramuscular hematoma can occur.
  • In these patients, the subcutaneous or intravenous routes can be used.

Undesirable / adverse effects

Many of the undesirable effects are associated with its anticholinergic properties. However, these effects are generally moderate and limited.

It can occur:

  • Dry mouth
  • Difficulty perspiring.
  • Fast heart rate.
  • Difficulty urinating.
  • Anaphylactic shock, anaphylactic reactions, shortness of breath, skin reactions (e.g., hives, rash, erythema, itching), and another hypersensitivity (allergy) reaction.



It is unknown if the milk is distributed; it is recommended that breastfeeding is not started if the mother is taking the drug.


Do not use during pregnancy.

General precautions

Do not take butylscopolamine if any following symptoms accompany abdominal pain.

This may be indicative of a more serious medical condition:

  • Nausea or vomiting
  • Severe constipation
  • Blood in the stool.
  • Fever.
  • Continuous abdominal pain (“mill” type).

In the following situations, do not take butyl scopolamine without consulting your doctor:

  • If you have heart disease.
  • If you have glaucoma.
  • If you have prostatism.
  • If you have a susceptibility to intestinal or urinary obstructions.
  • If the symptoms of abdominal pain or discomfort associated with colic are different than usual.
  • If the pain is sharp and sudden, intensity is more significant than usual or progressive intensity.
  • If you have an unexplained alteration of the gastrointestinal transit, such as diarrhea.
  • If you have unexplained weight loss.
  • If you have a specific clinical severe condition that requires medical monitoring.

In the following situations, you should stop taking butyl scopolamine and see a doctor immediately:

  • If the pain worsens during the first 24 hours of treatment.
  • If the pain lasts more than three days.
  • If you have a fever
  • If you feel intestinal fragility.
  • If you have rectal bleeding.
  • If you have repeated bleeding episodes.
  • If you have symptoms other than usual.

Suppose severe and unexplained abdominal pain persists or worsens or co-occurs with fever, nausea, vomiting, changes in bowel movements, abdominal tenderness, low blood pressure, fainting, or blood in the stool. In that case, it should be sought medical advice immediately.

Interrupted Therapy

  • If you forget to take a dose, take the following amount usually.
  • Do not take a double dose to make up for a forgotten dose.

Storage Care

  • Store below 25 ° C.
  • Store in the original container to protect from light and moisture.
  • Keep this medicine out of sight and reach of children.