Bonadoxin: How to Use, Caution, Side Effects and Interaction with Other Medications

It belongs to the class of medications called antiemetics (medicines that prevent nausea and vomiting).

Bonadoxin is used to prevent and relieve nausea, vomiting, and loss of balance associated with motion sickness, Meniere’s disease, and other inner ear problems.

How should I use this medication?

The recommended dose of bonadoxin in adults to treat motion sickness is a single dose of 12.5 mg to 25 mg every 24 hours. The first dose should be taken at least one hour before traveling (if you travel).

For disorders of the inner ear, the usual dose for adults ranges from 25 mg to 100 mg daily in divided doses. Fruit-flavored tablets can be chewed, swallowed whole or dissolved in the mouth.

Many factors can affect the dose of medication a person needs, such as body weight, other medical conditions and other medications.

If your doctor has recommended a different dose from those listed here, do not change the way you are taking the medication without consulting your doctor.

Bonadoxin should be taken with food to reduce the possibility of upset stomach.

It is important that you take this medication exactly as prescribed by your doctor. If you miss a dose of this medication, take it as soon as possible and continue your usual schedule.

If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for the one you forgot. If you are not sure what to do after skipping a dose, contact your doctor or pharmacist.

Store this medication at room temperature, protect it from light and moisture and keep it out of the reach of children.

Do not discard medicines in wastewater (for example, in the sink or in the toilet) or in household waste. Ask your pharmacist how to get rid of medications that are no longer needed or are no longer valid.


Do not take this medication if you are allergic to bonadoxin or any ingredient in the medication.

What side effects are possible with Bonadoxin?

Many medications can cause side effects. A side effect is an unwanted response to a medication when taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these effects can be controlled, and some may disappear on their own over time.

Contact your doctor if you experience these side effects:

  • Blurred or double vision.
  • Change in appetite (increase or decrease).
  • Constipation.
  • Diarrhea.
  • Dizziness.
  • Drowsiness.
  • Dry mouth, nose and throat.
  • Fatigue.
  • Headache.
  • Nausea.
  • Nervousness.
  • Acne.
  • Problems to sleep.
  • Stomachache.
  • Vomiting
  • Weight gain.
  • Signs of a severe allergic reaction
  • Abdominal cramps.
  • Difficult breathing
  • Swelling of the face and throat.

Some people may experience side effects other than those listed. Consult your doctor if you notice any symptoms that bother you while taking this medication.

Other precautions

Tell your doctor about any conditions you may have, if you are taking any medication, if you are breast-feeding or pregnant, and any other important information about your health.

These factors can affect the way you should use this medicine:

Asthma: Bonadoxin causes thickening of the mucous membranes in the lungs and can cause spasms in the muscles of the lungs, which worsens the symptoms of asthma.

People with asthma or other breathing problems should check with their doctor about how this medication may affect their medical condition, how their medical condition may affect the dosage and effectiveness of this medication, and if any special control is needed.

Drowsiness / reduced alertness : This medication may cause drowsiness. Do not drive, operate machinery, or perform other potentially hazardous tasks until you have determined how this medication affects you.

Enlarged prostate : Bonadoxin can worsen the symptoms of an enlarged prostate.

People with prostate problems should check with their doctor about how this medication may affect their medical condition, how their medical condition may affect the dosage and effectiveness of this medication, and if any special control is needed.

Glaucoma: Bonadoxin can worsen the symptoms of glaucoma.

People with narrow-angle glaucoma should talk to their doctor about how this medication may affect their medical condition, how their medical condition may affect the dosage and effectiveness of this medication, and if any special monitoring is needed.

Pregnancy : Studies on the use of bonadoxin by women who experienced nausea and vomiting during pregnancy did not reveal evidence of any birth defect caused by the medication.

However, this medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Lactation : Bonadoxin can reduce the amount of breast milk produced to a small degree. It should be used while breastfeeding only if the potential benefits outweigh the risks.

Children : The safety and efficacy of the use of this medication have not been established for children under 12 years of age. It is known that bonadoxin causes hyperexcitability when used by children.

What other drugs would interact with Bonadoxin?

  • Acetylcholinesterase inhibitors.
  • Alcohol.
  • Antihistamines
  • Antipsychotics
  • Barbiturates
  • Benztropina.
  • Bupropion.
  • Buspirona.
  • Butorfanol.
  • Carbamazepine
  • Cyclobenzapine.
  • Entacapone.
  • Dextroanfetamina.
  • Gabapentina.
  • Ipratropio.
  • Narcotic analgesics (For example, codeine, fentanyl, morphine).
  • Oxibutinina.
  • Scopolamine.
  • Tramadol.
  • Tricyclic antidepressants (eg, amitriptyline, desipramine).
  • Vigabatrin.
  • Zopiclone.

If you are taking any of these medications, talk to your doctor or pharmacist. Depending on your specific circumstances, your doctor may ask you to:

  • Stop taking one of the medications.
  • Change one of the medications to another.
  • Change the way you are taking one or both medications.
  • Follow the same plan.

An interaction between two medications does not always mean you should stop taking one of them. Talk to your doctor about how drug interactions are handled or controlled.

Tell your doctor or prescriber about all prescription, over-the-counter (OTC), and herbal medications you are taking.

Also tell them about any supplements you’re taking. Because caffeine, nicotine in cigarettes, or illegal drugs can affect the action of many medications, you should tell your doctor if you use them.