They are a cream compound used in the treatment of skin infections.
In addition to the three drugs that make up this cream, it is also made up of the following excipients:
- Liquid paraffin.
- White soft paraffin.
- Cetostearyl alcohol.
- Propylene glycol.
- Cetomacrogol 1000.
- Benzyl alcohol.
- Dehydrated sodium dihydrogen phosphate.
- Phosphoric acid
- Sodium hydroxide.
- Purified water.
This cream is indicated for the treatment of corticosteroid-sensitive dermatoses when complicated by infections caused by bacteria (sensitive to gentamicin) and fungi (sensitive to clotrimazole) or when the possibility of such infections is suspected.
The cream is suitable for eczema use.
Commonly a thin layer of the cream should be applied to completely cover the affected area and the surrounding areas 2 or 3 times a day.
It is recommended to follow the medical instructions. For greater effectiveness of treatment with betamethasone clotrimazole gentamicin it should be applied regularly.
The duration of therapy varies according to the extent and location of the disease and the patient’s response. However, if clinical improvement is not achieved within three to four weeks, the diagnosis should be revised.
Method of administration
Betamethasone, Clotrimazole, and Gentamicin Cream are for dermatological (topical) use only.
Special warnings and special precautions for use
- This compound medicine is contraindicated in those with a history or history of sensitivity and reactions to any of its components.
- If irritation or sensitization develops with the use of betamethasone clotrimazole gentamicin, treatment should be discontinued and appropriate therapy applied.
- Any of the side effects that are reported after systemic corticosteroid use, including adrenal suppression, can also occur with topical corticosteroids, especially in infants and children.
- Cross allergenicity between aminoglycosides has been demonstrated.
- Systemic absorption of topical corticosteroids or gentamicin will increase if large areas of the body surface are treated or if occlusive dressings are used, especially for prolonged periods of time or in the presence of dermal disruption.
- Gentamicin should be avoided in open wounds. In these cases, undesirable effects can occur after systemic use of gentamicin.
- Prudent use is recommended in these conditions, particularly in infants and children.
- Long-term use of topical antibiotics can occasionally result in an overgrowth of non-susceptible microorganisms.
- If there is irritation, sensitization or superinfection develops, treatment with labetamethasone, clotrimazole and gentamicin should be discontinued and the treating physician should be consulted.
- Clotrimazole gentamicin betamethasone cream is not for ophthalmic use.
- Pediatric Use : Pediatric patients may demonstrate greater susceptibility to topical corticosteroid-induced hypothalamic-pituitary-adrenal (HPA) axis suppression and exogenous corticosteroid effects than mature patients due to greater absorption.
Pregnancy and breastfeeding
This medicine is Category C for its gentamicin and betamethasone content.
As the safety of topical corticosteroid use in pregnant women has not been established, drugs in this class should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
This type of medication should not be used in excessive amounts or for prolonged periods of time in pregnant patients.
Since it is not known whether topical administration of corticosteroids can result in sufficient systemic absorption to produce detectable amounts in breast milk, a decision must be made to discontinue breastfeeding or to discontinue the drug, taking into account the importance of the drug for Mother.
Adverse reactions to betamethasone cream therapy have been reported very rarely and include:
- Discoloration of the skin.
- Burning or burning sensation.
- Itching .
Some adverse reactions of clotrimazole include:
- General skin irritation.
Gentamicin treatment has produced transient irritation that generally does not require discontinuation of treatment.
The following local adverse reactions have been reported with the use of topical corticosteroids especially under occlusive dressings:
- Burning sensation
- Acneiform eruptions.
- Hipopigmentación, perioral.
- Allergic contact dermatitis.
- Maceration of the skin.
- Secondary infection
- Atrophy of the skin.
- Stretch marks.
No interactions of the cream with other medications have been reported.
Special precaution for storage
Store in a cool place.