Artridol: Indications, Dosage, Mechanism of Action, Side Effects, Contraindications and Precautions

It is a drug with anti-inflammatory properties that combines the properties of a corticosteroid derivative with another non-steroidal component (indomethacin).

It also has analgesic properties that help relieve pain.

Presentation and Composition

  • Capsules:  25 mg of Indomethacin, 215 mg of Metocarbamol and 0.75 mg of Betamethasone.
  • Gel:  59 mg of betamethasone dipropionate and 500 mg of indomethacin.


It is used in the treatment of acute traumatic processes such as post-traumatic inflammation in tendons, ligaments and joints due to strains, strains and contusions.

It is also indicated in localized forms of soft tissue rheumatism, acute and subacute bursitis, shoulder-hand syndrome and periarthropathy (soft tissue inflammation) and acute gouty arthritis.

Also in localized forms of osteoarthritis of the peripheral joints and the spine (degenerative rheumatism).


Tablets:  In cases of rheumatoid arthritis and other rheumatic disorders, the recommended initial dose is one capsule every 8 hours for a period of 7 days.

The dose is gradually decreased, for one week, one capsule is administered every 12 hours for a period of 7 days, and finally the dose is reduced to one capsule every 24 hours for another seven days.

In the fourth week of treatment, reduce the dose until you reach a maintenance dose of one capsule every three days for a week until the treatment is complete.

The prescribed doses vary according to the type of disease, the severity and the response of the treatment.

Gel :  It should be applied twice a day, in the entire area of ​​pain that requires treatment, applying in sufficient quantity on the affected parts.

Mechanism of action

Indomethacin belongs to non-steroidal anti-inflammatories and has anti-inflammatory and analgesic properties similar to those of salicylates, which is a potent inhibitor of cyclooxygenase.

This enzyme forms the prostaglandins that intervene in the inflammatory process, as well as inhibits the mobility of polymorphonuclear leukocytes.

Methocarbamol is the muscle relaxant, whose mechanism of action is not yet established, but may be due to its general depressant effect on the central nervous system, its action is rapid.

Methocarbamol is also used in the symptomatic treatment of painful muscle spasms that are associated with musculoskeletal disorders.

Side effects

The oral artridol are similar to those presented by other corticosteroids .

Indomethacin can cause nausea and vomiting, anorexia, epigastric discomfort, abdominal pain, constipation, diarrhea, asthma and rash.

Methocarbamol can cause headache, blurred vision, dizziness and drowsiness.

Betamethasone for a long time can cause an increase in blood pressure, produces an increase in weight, moon face and acne.

It can also cause hyperglycemia, increases sensitivity to infections, osteoporosis, myopathy, behavioral changes, cataracts and growth arrest.

Artridol gel can cause the following side effects:

Cutaneous atrophy, folliculitis, hypertrichosis, acneiform rashes, burning sensation, itching, irritation, dryness, hypopigmentation, perioral dermatosis and allergic contact dermatitis, skin maceration, secondary infection and stretch marks.

Contraindications and precautions

  • The oral presentation is contraindicated in patients with systemic or infectious fungal infections, in patients with pathologies such as diabetes, hypertension, or peptic ulcers.
  • The gel presentation is contraindicated in cases of hypersensitivity to the components of the formula.
  • Indomethacin should not be administered in patients with coagulation problems.
  • The use of alcohol and other central nervous system depressants should be avoided.
  • It should not be administered in children under 12 years of age.
  • Prolonged use of the drug can cause subsequent subcapsular cataracts, glaucoma, and possible injury to the optic nerves.
  • Corticosteroids can raise blood pressure, and therefore the retention of salt and water and the excretion of potassium.
  • Its treatment must be reduced gradually, the suspension of abrupt form can cause secondary corticosuprenal insufficiency.
  • The use of artridol during pregnancy or in the period of lactation is not recommended.

Interactions with other medications

It may have interactions with the use of phenobarbital, rifampin, diphenylhydantoin or ephedrine, the use of other nonsteroidal anti-inflammatory drugs, anticoagulants, acetylsalicylic acid, and probenecid.

As well as thiazide diuretics, beta-adrenergic blockers and angiotensin-converting enzyme inhibitors, it can produce interactions with the components of artridol.