Artridol: Indications, Dosage, Mechanism of Action, Side Effects, Contraindications and Precautions

It is a drug with anti-inflammatory properties that combines the properties of a corticosteroid derivative with another nonsteroidal component (Indomethacin).

It also has analgesic properties that help relieve pain.

Presentation and Composition

  • Capsules:  25 mg of Indomethacin, 215 mg of Methocarbamol, and 0.75 mg of Betamethasone.
  • Gel:  59 mg of betamethasone dipropionate and 500 mg of Indomethacin.


It is used to treat acute traumatic processes such as post-traumatic inflammation in tendons, ligaments, and joints due to strains, strains, and contusions.

It is also indicated in localized soft-tissue rheumatism, acute and subacute bursitis, shoulder-hand syndrome, periarthropathy (soft tissue inflammation), and acute gouty arthritis.

Also, in localized forms of osteoarthritis of the peripheral joints and the spine (degenerative rheumatism).


Tablets:  In rheumatoid arthritis and other rheumatic disorders, the recommended initial dose is one capsule every 8 hours for seven days.

The dose gradually decreases; one capsule is administered every 12 hours for seven days for one week. Finally, the amount is reduced to one tablet every 24 hours for another seven days.


In the fourth week of treatment, reduce the dose until you reach a maintenance dose of one capsule every three days for a week until the treatment is complete.

The prescribed doses vary according to the type of disease, the severity, and the treatment response.

Gel It should be applied twice a day in the entire area of ​​pain that requires treatment and used in sufficient quantity on the affected parts.

Mechanism of action

Indomethacin belongs to nonsteroidal anti-inflammatories and has anti-inflammatory and analgesic properties similar to salicylates, a potent cyclooxygenase inhibitor.

This enzyme forms the prostaglandins that intervene in the inflammatory process and inhibits the mobility of polymorphonuclear leukocytes.

Methocarbamol is a muscle relaxant whose mechanism of action is not yet established but may be due to its general depressant effect on the central nervous system; its movement is rapid.

Methocarbamol is also used in the symptomatic treatment of painful muscle spasms that are associated with musculoskeletal disorders.

Side effects

The oral art idol is similar to those presented by other corticosteroids.

Indomethacin can cause nausea and vomiting, anorexia, epigastric discomfort, abdominal pain, constipation, diarrhea, asthma, and rash.

Methocarbamol can cause headaches, blurred vision, dizziness, and drowsiness.

Betamethasone for a long time can cause an increase in blood pressure and produces an increase in weight, moon face, and acne.

It can also cause hyperglycemia, increased sensitivity to infections, osteoporosis, myopathy, behavioral changes, cataracts, and growth arrest.

Artridol gel can cause the following side effects:

Cutaneous atrophy, folliculitis, hypertrichosis, acneiform rashes, burning sensation, itching, irritation, dryness, hypopigmentation, perioral dermatosis, allergic contact dermatitis, and skin maceration, secondary infection, and stretch marks.

Contraindications and precautions

  • The oral presentation is contraindicated in patients with systemic or infectious fungal infections and patients with pathologies such as diabetes, hypertension, or peptic ulcers.
  • The gel presentation is contraindicated in cases of hypersensitivity to the formula’s components.
  • Indomethacin should not be administered in patients with coagulation problems.
  • The use of alcohol and other central nervous system depressants should be avoided.
  • It should not be administered to children under 12 years of age.
  • Prolonged drug use can cause subsequent subcapsular cataracts, glaucoma, and possible injury to the optic nerves.
  • Corticosteroids can raise blood pressure and, therefore, the retention of salt and water and potassium excretion.
  • Its treatment must be reduced gradually; the suspension of the short form can cause secondary corticospinal insufficiency.
  • The use of art idols during pregnancy or in the period of lactation is not recommended.

Interactions with other medications

It may interact with phenobarbital, rifampin, diphenylhydantoin, ephedrine, other nonsteroidal anti-inflammatory drugs, anticoagulants, acetylsalicylic acid, and probenecid.

As well as thiazide diuretics, beta-adrenergic blockers, and angiotensin-converting enzyme inhibitors, it can produce interactions with the components of art idol.