Aceclofenac: Uses, Dosage, Side Effects, Interactions and Substitutes

It relieves pain in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.

It is a non-steroidal anti-inflammatory drug. It works by suppressing the production of chemical messengers (prostaglandins) that cause inflammation (redness and swelling), fever, and pain.

It is used for fever, headache, arthralgia, muscle pain, dental pain, postoperative pain, pain during menstruation, osteoarthritisrheumatoid arthritisankylosing spondylitis, and gout.

Aceclofenac (also available as Hifenac and Zerodol) is safe at the dose prescribed by the doctor. Patients should follow the advice of the doctor regarding its use.

It is a drug to relieve pain and not an antibiotic. It can reduce fever. However, could you consult your doctor regarding its use?.

Aceclofenac is structurally related and metabolized to diclofenac. Both are equally effective and safe in relieving pain. Patients should follow the doctor’s advice regarding its use.

Advice for Aceclofenac

  • It should be taken with food or milk to avoid an upset stomach.
  • It can cause serious complications, such as stomach bleeding and kidney problems if taken for a long time.
  • Aceclofenac may increase the risk of blood clots, heart attack, or stroke.
  • Tell your doctor if you are pregnant or plan to conceive or breastfeed.
  • Tell your doctor if you have ever been diagnosed with kidney or liver problems.

What is prescribed? Uses of Aceclofenac

Do not take this medicine if you have a known bleeding disorder, asthma, or allergy.


Before taking Aceclofenac

Some medications are not suitable for people with certain conditions, and sometimes medication can only be used if additional care is taken. For these reasons, before you start taking Aceclofenac, your doctor must know:

  • If you have ever had an allergic reaction to aspirin, naproxen, diclofenac, indomethacin, or any other medication.
  • If you have ever had a problem with your stomach or duodenal bleeding, as if you had an ulcer.
  • If you have asthma or any other allergic disorder.
  • If you have a heart condition or a problem with blood vessels or circulation.
  • If you are pregnant, trying to have a baby or breastfeeding.
  • If you have a problem with the way your liver works, or if you have a problem with the way your kidneys work.
  • If you have high blood pressure.
  • If you have ever had blood clotting problems.
  • If you have an inflammatory bowel disorder such as Crohn’s disease or ulcerative colitis.
  • Suppose you have a connective tissue disorder, such as systemic lupus erythematosus. This is an inflammatory condition that is also called lupus.
  • If you have a rare hereditary blood disorder known as porphyria.
  • Suppose you are taking other medications. This includes any medication you are accepting that is available to buy without a prescription and herbal medicines and complementary medicines.

How to take Aceclofenac

Before starting treatment, read the manufacturer’s printed information brochure from inside the package. It will give you more information about Aceclofenac and a complete list of the side effects you may experience while taking it.

Take Aceclofenac precisely as your doctor tells you to. The usual dose is a 100 mg tablet twice a day, preferably morning and evening.

Take Aceclofenac with food; during a meal is ideal. This will help protect your stomach from side effects, such as indigestion and stomach irritation. Swallow the tablet with a drink of water. Do not chew or crush the tablets.

If you forget to take a dose, take it as soon as you remember (unless it is almost time for your next dose, in which case, take the following amount when appropriate and skip the missed dose). Do not take two doses together to make up for the forgotten dose.

Can Aceclofenac cause problems?

Along with its beneficial effects, most medications can cause unwanted side effects, although not everyone experiences them. The table below contains some of the most common associated with Aceclofenac.

The best place to find a complete list of side effects associated with your medication is the printed information leaflet from the manufacturer that came with the drug.

Alternatively, you can find an example of the manufacturer’s information booklet in the reference section below. Talk to your doctor or pharmacist if any of the following continues or becomes bothersome.

Important: If you experience any of the following less typical but possibly severe symptoms, stop taking Aceclofenac and contact your doctor for advice immediately:

  • If you have breathing difficulties, such as wheezing or shortness of breath.
  • If you have any signs, such as swelling around your mouth or face or a rash with severe itching.
  • If you get blood or black stools, you draw blood or have severe abdominal pain.

If you experience other symptoms that you think may be due to the tablets, talk to your doctor or pharmacist for more information.

Significant and minor side effects of Aceclofenac:

  • Abdominal pain.
  • Constipation.
  • Diarrhea.
  • Nausea and vomiting.
  • Acne.

Contact your doctor immediately if you experience any of these symptoms regularly.

Highlights and frequent questions about Aceclofenac

All drugs interact differently from person to person. You should check all possible interactions with your doctor before starting any medication.

Start of action

The maximum effect of this medicine can be observed in 1.5 to 3 hours after oral administration.

Duration of the effect

This medicine is excreted in the urine, and the effect lasts from 12 to 16 hours.

Are you sure about alcohol?

This medicine should not be consumed with alcohol. The symptoms of stomach bleeding (such as dried blood and coffee in coughs or stools) should be reported to the doctor immediately.

Does it cause habit formation?

No habit formation trends were reported.

Disease interactions


Aceclofenac should not be taken if you have asthma sensitive to NSAIDs. Any history of this type should be informed to the doctor to make an adequate substitution.

Gastrointestinal toxicity:

Aceclofenac should be taken after consulting a doctor, especially if the expected duration is longer than one month. Any symptoms that indicate ulceration and bleeding, such as chronic indigestion, dry brown blood in the stool, or vomiting of blood, should be reported immediately.

Impaired renal function:

Aceclofenac should be taken after consulting a doctor if you have kidney disease. In such situations, an adequate adjustment of the dosage and control of renal functions is required.

Use in pregnancy and during lactation.

This medicine is not recommended for pregnant women or breastfeeding women.


The forgotten dose can be taken as soon as you remember it. However, you should skip the missed dose if it is almost time for your next dose. Do not consume more than the recommended dose.

A doctor should be contacted immediately if an overdose of Aceclofenac is suspected. Signs and symptoms of overdose include skin rashes, confusion, chest pain, blurred vision, etc. Immediate medical attention is needed if an overdose is confirmed.

You must carefully follow all instructions on the label. The doctor should prescribe the duration and amount of medicine consumed. It can be taken with food or after a meal. An adequate amount of water should be consumed to minimize irritation in the stomach.

List of substitutes for Aceclofenac

Below is the list of medications with the same composition, strength, and form as Aceclofenaco and, therefore, can be used as their substitute.

  • Arflur 100 MG in tablets of the pharmaceutical company FDC.
  • Dolobest 100 MG Tablets from the pharmaceutical company Ttk Healthcare.
  • Dolokind in 100 MG tablets from the pharmaceutical company Mankind Pharmaceuticals.
  • 100 MG Mobiride tablets from the pharmaceutical company Merck Consumer Healthcare.
  • 100 MG Movace tablets from the pharmaceutical company Laboratorio Alkem.

Make the most of your treatment.

Your doctor will try to prescribe the lowest dose for the shortest time to reduce the risk of side effects. If you need to take Aceclofenac for some time, your doctor may prescribe another medication to protect your stomach from irritation.

Try to meet your regular appointments with your doctor. This is so your doctor can verify your progress.

If you have asthma, symptoms such as wheezing or dyspnea can worsen with anti-inflammatories such as Aceclofenac. If this happens to you, you should stop taking the tablets and consult your doctor as soon as possible.

It is known that there is a slight increase in the risk of heart and vascular problems in people who take long-term anti-inflammatory analgesics. Your doctor will explain this to you and prescribe the appropriate lower dose for the shortest possible time to reduce the risk.

If you buy any medication, consult a safe pharmacist to take it with an anti-inflammatory such as Aceclofenac. It would help if you did not take these tablets with any other anti-inflammatory pain relievers, some of which are available in cold and flu remedies that can be purchased ‘over the counter.

If you have an operation or dental treatment, tell the person doing the therapy what medications you are taking.