Index
Benign prostate enlargement is a problem that can occur in men as they age.
Secotex is used to treat men who have symptoms of an enlarged prostate , which is also known as benign prostate enlargement ( benign prostatic hyperplasia, or BPH).
As the prostate enlarges, some muscles of the gland can contract and since the prostate is below the bladder, it can press on the tube that drains urine from the bladder.
This pressure can cause problems with urination, such as: the need to urinate frequently, a weak stream when urinating, or the feeling of not being able to empty the bladder completely.
Chemical formula of Secotex
- The active ingredient is tamsulosin C20H28N2O5S • HCl.
Presentation
The presentation for the commercialization of Secotex is in 0.4 mg coated capsules.
Indications of Secotex
Secotex is a drug used to treat enlarged prostate, painful urination, urinary frequency and urgency, and other conditions.
Mechanism of action
Secotex helps to relax the muscles of the prostate and the opening of the bladder, increasing the flow of urine and relieving symptoms.
However, Secotex will not shrink the prostate, the prostate can continue to enlarge and this can make symptoms worse over time.
Therefore, even though Secotex may lessen the problems caused by an enlarged prostate now, surgery may be necessary in the future.
Dose
Secotex 0.4 mg capsule once daily is recommended as the dose for treating the signs and symptoms of benign prostatic hyperplasia.
Secotex capsules should not be crushed, chewed or opened.
After 2 to 4 weeks of treatment, if a patient response to the 0.4 mg dose is not observed, the dose can be increased to 0.8 mg once daily.
If the Secotex capsules are suspended or interrupted for several days with the 0.4 mg or 0.8 mg dose, therapy should be started again with the 0.4 mg dose once daily.
Side effects of Secotex
The most commonly reported side effects of Secotex tablets are:
- Drowsiness.
- Difficulty falling asleep or staying asleep.
- Asthenia or weakness.
- Back pain.
- Diarrhea .
- Runny or stuffy nose.
- Pain or pressure in the face sore throat, cough, fever, chills, or other signs of infection.
- Blurred vision, dizziness, headache.
- Palpitations and orthostatic hypotension .
- Nausea and vomiting
These side effects are possible, but they don’t always happen.
Some of the side effects can be rare but serious. A doctor should be consulted if any of the following side effects are observed, especially if they do not go away.
Warnings and Contraindications
Hypersensitivity to Secotex is a contraindication.
Patients known to be hypersensitive to Secotex or any component of the capsules should not be given the drug.
Reactions have included rash, hives , pruritus , angioedema, and respiratory symptoms.
Also, Secotex should not be used if you have the following conditions:
- Having undergone surgery.
- Kidney disease
- Liver disease
- Prostate cancer.
Secotex interactions
Among the drugs known to interact with Secotex are cimetidine, which concomitantly causes an increase in Secotex plasma levels, while furosemide causes a drop (approximately 12% after a single dose of 20 mg per dose). intravenously).
Secotex is extensively bound to plasma proteins and may displace other protein-bound drugs. No dose adjustment is necessary, since these plasma levels remain within normal values.
Concurrent administration of Secotex with other α1 adrenergic receptor antagonists is contraindicated due to the potential for hypotensive effects.
No interactions at the level of hepatic metabolism have been observed during in vitro studies with microsomal fractions of the liver (representative of the system of metabolizing enzymes of drugs linked to cytochrome P-450), involving amitriptyline, salbutamol, glibenclamide and finasteride.
The elimination rate of Secotex can be increased with the concomitant use of diclofenac and warfarin.
The use of Secotex capsules is contraindicated in combination with strong CYP3A4 inhibitors, such as ketoconazole.
