Index
It is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties.
Formulation
Each bristaflam tablet contains:
Aceclofenaco: 100 mg.
Anti-inflammatories like aceclofenac are also known as non-steroidal anti-inflammatory drugs (NSAIDs) or sometimes just anti-inflammatory pain relievers .
Indications
The use of bristaflam is indicated in the following conditions:
For the relief of pain and inflammation in osteoarthritis , rheumatoid arthritis, and ankylosing spondylitis.
Osteoarthritis
To treat symptoms such as joint stiffness, painful knee, hip, neck, and lower back joints associated with osteoarthritis.
Rheumatoid arthritis
To treat symptoms such as joint stiffness, pain, and swelling associated with rheumatoid arthritis.
ankylosing spondylitis
To treat the symptoms of ankylosing spondylitis, such as spinal stiffness and pain.
Other uses
Among its other uses, bristaflam can also be indicated in cases of:
- Fever.
- Dental pain.
- Headache.
- Postoperative pain.
Mechanism of action
Bristaflam potently inhibits the enzyme cyclooxygenase (COX) that is involved in the synthesis of prostaglandins, which are inflammatory mediators that cause pain, swelling, inflammation, and fever. It is administered orally.
It shows high permeability to penetrate the synovial joints, where in patients with osteoarthritis and related conditions, the loss of articular cartilage in the area leads to joint pain, tenderness, stiffness, crepitus, and local inflammation.
Aceclofenac is also reported to be effective in other painful conditions, such as dental and gynecological conditions.
In 1991, the active substance in bristaflam, aceclofenac, was developed as an analog of a commonly prescribed NSAID, through chemical modification in an effort to improve the drug’s gastrointestinal tolerability.
Absorption and excretion
Absorption
Aceclofenac is rapidly and completely absorbed from the gastrointestinal tract and circulates primarily as unchanged drug after oral administration.
Peak plasma concentrations are reached about 1 to 3 hours after ingestion, and the drug penetrates the synovial fluid where the concentration can reach up to 60% of that in plasma.
There is no accumulation at regular dosing, with a similar peak plasma concentration (Cmax) and time to reach peak plasma concentration (Tmax) after single and multiple doses.
Route of elimination
The main route of elimination of aceclofenac is through the urine, where elimination represents 70-80% of the clearance of the drug.
Approximately two-thirds of the administered dose is excreted in the urine, mainly as glucuronidated and hydroxylated forms of aceclofenac. About 20% of the dose is eliminated in the faeces.
Dosage and administration
The bristaflam tablet is generally indicated to be taken twice a day, commonly in the morning and in the evening.
Take the whole tablet with a glass of water, never crush or chew the tablets.
It can be taken during the meal or after eating. drinking an adequate amount of water is recommended to minimize the chances of indigestion and stomach irritations.
Missing dosage
If you miss the dose, take it as soon as possible, and if it is close to the next dose, skip the missing dose, continue with regular dosing. Do not take extra doses.
Overdose
Taking more than prescribed can cause harmful side effects. Consult your doctor or pharmacist if you find any side effects.
Contraindications
Bristaflam is contraindicated in the following conditions:
Allergy
Avoid if you have an allergy to aceclofenac or other NSAIDs
Bleeding
If you have a bleeding disorder, aceclofenac is not recommended for you. It could cause severe swelling and bleeding in the intestines, stomach, and anus.
Warnings and cautions
- If you have black or bloody stools, see your doctor.
- Do not take if you are allergic to aceclofenac.
- The effect of aceclofenac can last 8 to 12 hours.
- It is not totally safe to take during pregnancy and lactation so it should be avoided.
- Keep these medicines out of children.
- If you experience drowsiness, dizziness, you should not drive or use machinery.
- If your doctor prescribes aceclofenac medicine for you, tell your doctor about all the medicines you are using for heart, kidney, asthmatic and gastric problems.
- It should not be given to people with porphyria (a group of disorders that affect the nervous system, skin, and other organs).
Possible side effects
Besides the desired effect, bristaflam can cause some unwanted effects as well. If you experience any of the following side effects see your doctor immediately.
- Acne.
- Abdominal pain.
- Constipation .
- Vomiting
- Dizziness
- Sickness.
- Diarrhea.
Interactions with other medications
Bristaflam can interact with other medications, so it is recommended to inform your treating physician if you are using other medications or should use other medications, including natural treatments.
This is especially important if you are taking lithium, digoxin, diuretics, blood thinners, and pain relievers.
Other presentations of bristaflam
- Injection.
- Dust.
- Gel.
Storage
- Protect from light, moisture and heat.
