Bilobil: Composition, Indications, Mechanism of Action, Dosage, Side Effects and Interactions

Contains standardized extract of Ginkgo biloba leaves, which improves blood circulation and brain supply with oxygen and glucose.

Bilobil is suitable for people with severe memory and concentration disorders, while helping with noise problems in the ears, vertigo and circulation disorders of the extremities.

Bilobil improves metabolism and blood circulation in the brain, thus improving psycho-intellectual functions .

In disorders of infusion of blood in the extremities, it improves the sensation of cold, tingling, numbness and pains that occur when walking.


The active principle is a dry, purified and quantified extract of Ginkgo biloba leaves.

The active substances in this extract are flavonoid glycosides, ginkgolide and bilobalide, which correspond to:

  • 26.4 to 32.4 mg of flavonoids, expressed as flavone glycosides.
  • From 3.36 to 4.08 mg of ginkgolide A, B, C.
  • From 3.12 to 3.84 mg of bilobalide.
  • Extraction solvent: 60% (w / w) acetone.

The other ingredients are lactose, cornstarch, talc, anhydrous colloidal silicon dioxide and magnesium stearate in the capsule core and black iron oxide, red iron oxide, yellow iron oxide, titanium dioxide and gelatin in the capsule shell.

The auxiliary in the preparation of the plant is liquid glucose, prepared by drying and pulverizing.


Bilobil is sold in capsules containing 120 mg of dried ginkgo biloba leaf extract.


Bilobil capsules are recommended for brain disorders, such as:

  • The decline of memory and intellectual abilities.
  • Vertigo
  • The noise in the ears.
  • Sleep disorders and headaches.

Bilobil is also recommended in early limb circulation disorders, along with appropriate physical therapy, in particular: walking.

Mechanism of action

They dilate blood vessels, improve blood flow, prevent platelet aggregation, improve circulation, and increase oxygen and glucose intake.

By regulating metabolism, it protects cells and tissues against injury caused by lack of oxygen.

Bilobil, Ginkgo biloba extract, is effective in blood perfusion disorders in the brain and extremities.


The recommended dose of Bilobil is:

  • From 120 to 240 mg of dry extract of Ginkgo biloba leaves divided into 2 to 3 meals in the symptomatic treatment of chronic neurosensory and cognitive deficits in the elderly.
  • 120 mg to 160 mg dry divided into 2 to 3 doses after meals, in the symptomatic treatment of chronic obliterating arteriopathy of the lower extremities and the development of Raynaud’s syndrome.
  • 80 mg 2 to 3 times a day in disorders of vascular origin of visual acuity and field of vision.

Side effects

Like all medicines, Bilobil can cause side effects, although not everyone gets them.

In very rare cases, Bilobil can cause mild digestive disorders, headaches, or skin hypersensitivity reactions.

If a hypersensitivity reaction occurs, the capsules should be stopped.

Warnings and Contraindications

Bilobil should not be used in the following cases:

Bilobil will not be administered if you have had hypersensitivity reactions, allergies, to the extract of the Ginkgo biloba leaf or to any of the excipients of the medicine.

The use of Bilobil capsules in children is not recommended.

Parahydroxybenzoates are known for the determination of
allergic phenomena such as urticaria.

They usually cause delayed reactions like contact dermatitis.

It rarely causes immediate reactions with hives and bronchospasm.

Bilobil capsule contains lactose. Due to the presence of lactose, this drug is not recommended for patients with congenital galactosemia, glucose malabsorption, and lactase deficiency.

There are no clinical data on the use of the drug during pregnancy and lactation.

Although studies in animals have not shown harmful effects on the fetus, the use of the product in pregnant or nursing mothers is not recommended.


If you are taking or have recently taken other drugs, the drug interaction should be checked in the package leaflet.

It is not recommended to administer Bilobil concomitantly with acetylsalicylic acid or with continuous treatment with anticoagulants.

Concomitant administration of these drugs may increase the risk of bleeding due to the long clotting time.

If Bilobil is used concomitantly with an antiepileptic drug , the seizure threshold may decrease and the risk of seizures increases.