Dicynone: Uses, Mechanism of Action, Pharmacology, Side Effects, Precautions, How to Use, Contraindications and Pregnancy

It is used for capillary hemorrhage, neonatal intraventricular hemorrhage, hematuria, epistaxis, secondary bleeding due to thrombocytopenia, and other conditions.

The Dicynone tablet contains Ethamsylate as an active ingredient. It works by improving the adhesiveness of platelets and restoring capillary resistance.

Detailed information regarding the uses, composition, dosage, side effects, and reviews of the Dicynone tablet is detailed below.

Uses of Dicynone tablet

Dicynone tablet is used in the treatment, control, prevention, and improvement of the following diseases, conditions, and symptoms:

  • Capillary bleeding
  • Hemorragia intraventricular neonatal.
  • Hematuria.
  • Epistaxis.
  • Secondary bleeding due to thrombocytopenia.

The Dicynone tablet may also be used for purposes not mentioned here.

Other types of Uses

  • In surgery: Prevention and treatment of previous or postoperative hemorrhages in all delicate operations and those that affect highly vascularized tissues: gynecology, obstetrics, urology, odontostomatology, ophthalmology, plastic and reconstructive surgery.
  • In internal medicine:  Prevention and treatment of capillary hemorrhages of any origin or location; hematuria, hematemesis, epistaxis, gingivorragia.
  • In gynecology:  Metrorrhagia, primary menorrhagia or related to the IUD in the absence of organic pathology.

Mechanism of Action and Pharmacology

When the etamsylate is administered, it is slowly absorbed in the gastrointestinal tract. After oral administration of 500 mg of ethamsilate, the maximum level in plasma, i.e., 151 μg / ml, is reached at four h, but bioavailability is unknown.

The binding speed to plasma proteins is approximately 95%. The plasma half-life is approximately 3.7 h. About 72% of the administered dose is excreted in the first 24 h in the urine, and the molecule is passed without changes.

Etamsylate crosses the placental barrier. Maternal and umbilical cord blood contains similar concentrations of etamsylate.

It is not known if etamsylate is excreted in breast milk.

It is unknown whether etamsylate’s pharmacokinetic properties are modified in patients suffering from impaired renal or hepatic function.

The Dicynone tablet improves the patient’s condition by performing the following functions:

  • Improvement of the adhesiveness of platelets and restoration of capillary resistance.
  • Ethamsato.

Keep in mind that this medication may be available in several strengths for each active ingredient mentioned above.

Side effects

Etamsylate is a synthetic anti-hemorrhagic and radioprotective drug that acts in the first step of hemostasis (endothelium-platelet interaction).

Improving the adhesiveness of platelets and restoring capillary resistance reduces bleeding time and blood loss.

Ethamsylate has no vasoconstrictive action and does not influence fibrinolysis or modify plasma coagulation factors.

The following is a list of possible side effects that may occur from using Dicynone Tablet.

These side effects are possible, but they do not always occur. Some of the side effects can be rare but serious. Consult your doctor if you notice any of the following side effects, especially if they do not go away:

  • Allergic rejection
  • Sickness.
  • Acne.
  • Vomiting
  • Fever.
  • Diarrhea.

The Dicynone tablet can also cause side effects not mentioned here.

If you notice other side effects not mentioned above, contact your doctor for medical advice. You can also report side effects to your local food and drug administration authority.

Precautions and How to Use

Before using the Dicynone tablet, tell your doctor about your current list of medications, over-the-counter products (e.g., vitamins, herbal supplements, etc.), allergies, pre-existing conditions, and current health conditions (e.g., pregnancy, upcoming surgery, etc.).

Some health conditions may make you more susceptible to the side effects of the medication. Take as directed by your doctor or follow the address printed on the product leaflet.

The dose is based on your condition. Tell your doctor if your condition persists or worsens. The essential points of advice are listed below:

  • Consult a doctor if you have acute porphyria, fever with treatment, non-cancerous growths, or blood pigment disorder.
  • Do not use before the onset of bleeding during periods.
  • Notify your doctor if you are allergic to sulfites or wheat.
  • Pregnant or breastfeeding a baby.
  • Consult your doctor if you have allergic reactions or allergies to sulfonamides or wheat.

Contraindications

Hypersensitivity to the Dicynone tablet is a contraindication. In addition, the Dicynone tablet should not be used if you have the following conditions:

  • Hypersensitivity

Dose:

Adults:

  • Pre-surgical : 1 tablet (500 mg) 1 hour before surgery Pos / -surgery: 1 tablet (500 mg) evel) ‘4 – 6 hours after the risk of bleeding persists.
  • Medication: usually one tablet 2 – 3 times a day (1000 – 1500 mg) to be taken with meals with a little water: the duration of treatment depends on the results obtained.
  • Gynecology: metrorrhagia one tablet three times a day (1500 mg) with meals with a little water. The treatment lasts 1.0 days and begins five days before the expected start of menstruation.

Children:

Due to its high concentration of active principle, Dicynone 500 is not appropriate for children.

Pregnancy and breastfeeding

Pregnancy Category C: studies on pregnant women or animals are not available.

As a precaution, Dicynone 500 should not be administered during the first trimester of pregnancy while during the second and third trimesters.

It should be administered only if the expected therapeutic benefit is superior to the fetus’s potential risk.

In the absence of data on the passage to breast milk, breastfeeding is not advisable during treatment, or, if breastfeeding should be continued, treatment should be discontinued.