In medicine, the presence of elevated levels of transaminases, can be an indicator of liver damage . Transaminases are enzymes that have a metabolic activity in cells. These enzymes are present in various tissues (liver, heart, kidneys and muscles) reflect the activity of the liver and the heart.
The liver has transaminases to synthesize and break down amino acids and convert energy storage molecules, also called plasma, at normally low levels.
However, if the liver is damaged, the membrane of liver cells (hepatocytes) becomes more permeable and some of the enzymes escape into the bloodstream.
Elevated levels are sensitive to liver injury, which means you are likely to be present if there are injuries. However, they can also be elevated in other conditions, such as thyroid disorders, celiac disease, and muscle disorders.
The measurement of high transaminases is used in the diagnosis of heart attacks, although they have been replaced by new tests of enzymes and proteins that are more specific for heart damage.
The possible causes of high levels are inflammation of the liver (hepatitis A, B, C, infectious mononucleosis, acute viral fever, alcohol, pancreatic disorder), injury to the muscles (trauma, myocardial infarction, congestive heart failure, insufficiency acute renal), and many toxins and drugs.
Treatment for High Transaminase
- Antiviral drugs reduce hepatic enzymes elevated by hepatitis C.
- Take diuretics as prescribed by the doctor. The doctor can prescribe antibiotics
- Stop drinking alcohol immediately. Do not drink alcohol after it has recovered.
The results of a blood test are never enough to make a diagnosis, regardless of the dose taken. Only the doctor can dictate a diagnosis after comparing these results with the questioning of the patient, the clinical examination and other possible test results.
On the other hand, there are high transaminases with chronic elevation when there is evidence of levels higher than 1.5 times the upper limit of normal.
Do not worry, without getting the opinion of your doctor, he is the one who can tell you if there is any complication
The increase in transaminases does not necessarily reflect an anomaly. It is necessary to carry out other exams. A blood test of liver activity is also usually done, including at least the blood test, alkaline phosphatase and bilirubin.
A decrease in transaminases may be related to pregnancy or vitamin B6 deficiency.
Elevation of Transaminases
An increase of transaminases in the blood occurs when there is destruction of the cells of the liver, and this in all the diseases of the liver: viral, infectious or toxic hepatitis, liver cancer. These high levels of transaminases can also be related to autoimmune disease, obesity and overweight, alcoholism, myopathy, myocardial infarction, parasites or pancreatitis.
It should be noted that muscular efforts or muscle trauma can increase transaminase levels. People over 60 may also have high blood levels of transaminases.
Contraceptives and anti-epileptic medications can alter transaminases in the blood.