Sustanon 250: Uses, Mechanism of Action, Contraindications, Side Effects, Administration and Interactions

We are talking about an amazingly versatile type of testosterone.

Injectable Sustanon 250 (Testosterone) is a treatment to increase low testosterone levels.

What is Sustanon injection used for?

Sustanon 250 via injection is prescribed to men with low natural testosterone levels as a testosterone booster or testosterone replacement therapy.

Sustanon injections are also prescribed for female-to-male transsexuals to aid the hormonal transition and allow the development of male sexual characteristics, such as the growth of body hair and deepening of the voice.

How do Sustanon injections work? (Mechanism of action)

Sustanon injection contains testosterone esters (Testosterone Propionate, Phenylpropionate, Isocaproate, and Decanoate). These are derived from the male sex hormone testosterone, produced naturally by the testes.

Testosterone is the primary hormone essential for the average growth, development, and function of male sex organs and male sexual characteristics.

Testosterone is essential for sperm production, sexual desire, achieving an erection, and functioning of the prostate and other reproductive structures.


It also has functions in the skin, muscles, skeleton, kidney, liver, bone marrow, and central nervous system.

Natural testosterone levels decline slowly with age and fall rapidly after surgical removal of the testicles (for example, in the treatment of testicular cancer).

Levels can also drop due to testicular disease (hypogonadism or eunuchoidism) or disease of the pituitary gland (a gland in the brain that controls hormone production).

Low testosterone levels can cause symptoms such as:

  • Decreased sexual desire
  • Erectile dysfunction (impotence).
  • Infertility
  • Fatigue.
  • Depressed mood
  • Weakening of the bones (osteoporosis).

Testosterone replacement allows natural testosterone levels to return to normal and alleviates deficiency symptoms.

Key facts about Sustanon

Sustanon 250 is a brand name for testosterone. The injections are usually given once every three weeks.

Sustanon injections are on the list of substances banned in sports by the World Anti-Doping Agency (WADA). The misuse of Sustanon injection to enhance fitness in sports carries serious health risks.

Who should not get Sustanon injections? (Contraindications)

Sustanon is not suitable for anyone with:

  • Prostate cancer
  • Breast cancer
  • An allergy to peanuts or soy (the shot contains Arachis oil).

Also, some people may need extra monitoring while receiving Sustanon injections.

Make sure your doctor knows if you have:

  • Symptoms of prostate problems, such as urination problems: Testosterone can increase the growth of prostate cancers and benign prostate enlargement. Your doctor will perform several tests to make sure you do not have prostate cancer before you start receiving injections of Sustanon, and you will need to check your prostate at least once a year during treatment.
  • Kidney or liver disease.
  • Heart disease: for example, heart attack or heart failure.
  • High blood pressure (hypertension).
  • Epilepsy.
  • Diabetes.
  • A history of migraines.
  • A condition called sleep apnea (when breathing temporarily stops during sleep).
  • If you are overweight or have chronic lung disease, you may be more likely to develop this problem.
  • Cancer.
  • An increased risk of getting blood clots (thrombophilia).

If you are transsexual, you should tell your doctor if you or anyone in your family has ever had breast or endometrial cancer.

How is Sustanon administered?

Injecting Sustanon 250 via injection is called depot injection. It is injected deep into a muscle, for example, the buttock, thigh, or upper arm, where it forms a reservoir of testosterone that is gradually released into the bloodstream.

The injection is usually given once every three weeks for testosterone replacement therapy.

The injection can be given once every two to four weeks for female-to-male transsexuals, usually as part of a surgery treatment program.

What are the side effects of Sustanon?

Medicines and their possible side effects can affect people in different ways.

The following are some of the side effects that may be associated with Sustanon injections:

Just because a side effect is stated here does not mean that all people who undergo Sustanon injections will experience that or any side effect:

  • Injection site reaction.
  • Increased levels of red blood cells and hemoglobin in the blood.
  • Headache.
  • Feeling sick.
  • Mood swings, including depression, nervousness, anxiety, or irritability.
  • Change in sexual desire
  • Breast pain, breast enlargement.
  • Persistent and painful erection of the penis (priapism).

Consult a doctor if:

  • You have an erection that lasts more than four hours.
  • Decreased sperm count.
  • Prostate problems include prostate gland growth, increased PSA levels, and prostate cancer.
  • Fluid retention (edema)
  • Increased blood pressure (hypertension).
  • Weight gain.
  • Muscle or joint pain.
  • Male pattern hair loss.
  • Acne.
  • Itch.
  • Elevated cholesterol levels.
  • Sleep apnea (when breathing temporarily stops during sleep).
  • Liver problems

Read the leaflet that comes with the medicine or talk to your doctor, nurse or pharmacist if you want more information about the possible side effects of Sustanon injection.

Common side effects of testosterone therapy include:

  • Acne.
  • Increase in body and facial hair.
  • Male pattern baldness.
  • Anxiety.
  • Irritability.
  • Depression.
  • Fluid retention.
  • Weight gain.
  • Breast enlargement.
  • Prostate problems and frequent erections.

If you receive long-term treatment with Sustanon, you will need regular blood tests to monitor your testosterone level, red blood cells, liver function, cholesterol levels, and prostate-specific antigen (PSA) levels.

 Can I use other medications with Sustanon 250? (Interactions)

It is essential that you tell your doctor or pharmacist if you are already taking any medicines, including those bought without a prescription and herbal medicines, before starting treatment with Sustanon.

It is also good to check with your doctor or pharmacist before taking any new medications while on this treatment to make sure the combination is safe.

Some key points are:


Testosterone can increase the blood-clotting effects of coumarin anticoagulants, such as warfarin, nicoumalone, and phenindione.

If you take one of these, your blood clotting time (INR) may need to be monitored more often.


You are more likely to get fluid retention and swelling (edema) if you use corticosteroids such as dexamethasone with testosterone, as both drugs can cause fluid retention.

This combination of drugs should be used with caution in people with heart, liver, or kidney disease.

Medications for diabetes

If you have diabetes, you may need to reduce your dose of insulin or diabetes pills after starting testosterone treatment.

What other medicines contain testosterone?

  • Nebide injection.
  • Restandol cystocarps.
  • Striant SR buccal tablets.
  • Testim gel.
  • Testogel.
  • Enanthate Testosterone Injection.
  • Testosterone implant.
  • Gel toast.
  • Virormone injection.