Paraproteinemia or Monoclonal Gammapathy: What is it? Symptom and Treatment

It is the presence of high paraproteins or monoclonal gammaglobulins in the blood.

It is also known as monoclonal gammopathy, which occurs due to immunoproliferative disorders such as leukemias, lymphomas, and plasma cell dyscrasia or cancers. This condition can occur due to the manifestation of a disease without a known cause, such as monoclonal gammopathy. The diagnosis depends on detecting abnormal immune proteins in the blood, and the treatment involves the management of the underlying cause.

Paraprotein comes from a single stem cell through multiple repetitions, which, in general, are essentially clones of each other. Monoclonal cells are characteristic of cancer cells. A type of B cell called a plasma cell produces gamma globulins in abundant amounts causing leukemias and lymphomas, such as B cells and non-Hodgkin lymphomas, to lead to paraproteinemias.

Symptoms of Paraproteinemia

Side effects that must be pending; Pay special attention to the following side effects and notify your doctor immediately if you have any:

There are strange bruises or signs of bleeding in the gums, nose, digestive tract, vagina (in women), fainting, dizziness, loss of consciousness, or skin rash.


The exchange of plasma (PE) and intravenous immunoglobulin (IVIG) is effective in disease-modifying treatments. Clinical studies have shown the efficacy of oral prednisolone and corticosteroids, which are usually the most appropriate treatment. Currently, the effectiveness of interferon beta and alpha is under investigation. Demyelinating neuropathies associated with circulating paraproteins are clinically heterogeneous, depending on the reactivity and type of the monoclonal protein (M).

Laboratory and Diagnostic tests

Blood tests to evaluate abnormal clotting in people who develop abnormal bruising or signs of bleeding.