Leukoclastclastic Vasculitis in the Skin: Causes, Symptoms and Treatment



It is the inflammation of small blood vessels in the body. The prognosis and treatment is very frustrating, as it leads to bleeding and in some cases damage to the surrounding tissues. People who suffer from this disease, may experience an acute attack, or become chronic and repeated several times.

The skin is the main area where leukocytoclastic vasculitis manifests, especially in the legs, although it can occur in other parts of the body.

Changes occur with small purple or red spots , with bleeding under the skin and can usually be painful or itchy. The lesions can be small or grow together to form more spots. In some cases, the purple obstructs the blood flow in the skin, causing tissue death, or necrosis.

Leukocytoclastic vasculitis can also occur internally, affecting certain organs, usually the kidneys or parts of the gastrointestinal tract, although the heart, lungs, joints, and nervous system may also be affected.

Causes of leukocytoclastic vasculitis

Infections: Occurs in response to an infection.

Diseases of the immune system:  Vasculitis can also occur as a result of some diseases of the immune system, such as rheumatoid arthritis, lupus and scleroderma.

Allergic reactions:  Sometimes an allergic reaction to a medication can cause vasculitis.

Cancer of cells in the blood:  It affects blood cells, including leukemia and lymphoma, causing leukocytoclastic vasculitis.


  • Purple spots on the skin
  • Skin sores mostly located on the legs, hips or trunk
  • Blisters on the skin
  • Hives (urticaria) that can last more than 24 hours
  • Open sores with dead tissue (necrotic ulcers).


  • The elevation of the legs or compression stockings can be useful because the disease usually affects the dependent areas.
  • Elimination of the causative drug of Vasculitis Leukocytoclastic.
  • Treat the chronic disease that mainly affects the skin with non-toxic modalities whenever possible; avoid the use of systemic corticosteroids and / or immunosuppressive agents.
  • Patients with ulcerative disease often require a short use of systemic corticosteroids to achieve disease control more quickly
  • Patients with progressive or chronic skin disease may need systemic corticosteroids and / or steroid sparing agents such as azathioprine, methotrexate or mycophenolate mofetil.
  • The use of Rituximab for patients with leukocytoclastic vasculitis , particularly those with neutrophil antibodies.