Endogenous Depression: Causes, Symptoms, Types, Differences, Diagnosis and Treatment

It usually has a genetic component, so if there is a family tendency to depression, it may have an effect, although it is not a determining factor.

Depression can not be defined as a single disorder but rather as a primary name for several disorders that have an almost similar type of symptoms. But the causes can differ depending on the individual mental state and, consequently, doctors offer different treatment options.

Here we are going to talk about Endogenous Depression, several causes associated with it, ways to identify the problem and potential treatments offered in the medical world. Keep reading the details below to gather the most important information.

What is endogenous depression?

In most cases, depression is encouraged by certain intolerable events or, probably, when something serious happened to the person in the growth stage.

Patients with severe endogenous depression often have biochemical hypercortisolism. Plasma cortisol and urinary steroid excretion are increased, and are not normally suppressed in dexamethasone tests at low doses.

Activation of the pituitary-adrenal axis in depression can be observed in up to 40-60% of patients in some series, with normal or slightly increased plasma adrenocorticotropic hormone levels.

Depressed patients have an adrenocorticotropic hormone response in plasma attenuated to corticotropin-releasing hormone compared to normal controls, but their basal levels of plasma cortisol are elevated and respond normally to corticotropin-releasing hormone.

These results indicate that the pituitary corticotrope is intrinsically normal, with the attenuated response of the adrenocorticotropic hormone to the corticotropin-releasing hormone, which shows that they are sensitive to the negative feedback of the increase in cortisol levels (the opposite occurs in Cushing’s disease). ).

The normal response of cortisol to corticotropin-releasing hormone, despite the sudden increase in adrenocorticotropic hormone, is compatible with hyperplasia and hyperresponsiveness of the adrenal cortex, as reported in depressed patients.

The dynamics of adrenocorticotropic hormone is similar to that observed in normal subjects who were given long-term infusion of corticotropin-releasing hormone and, therefore, point to the hypothalamus or supra-hypothalamic regions as the main cause of adrenocorticotropic hormone hypersecretion. .

Although the source and importance of the corticotropin-releasing hormone of cerebrospinal fluid are debated, the finding that depressed patients have increased levels of corticotropin-releasing hormone in the cerebrospinal fluid.

This finally seems to correlate positively with the degree of pituitary-adrenocortical hyperactivity, it has been taken as another indication that this condition is due to a hypothalamic dysfunction with overproduction of corticotropin-releasing hormone.

The hypercortisolémic state that accompanies depression often creates a serious diagnostic challenge. A depressed patient may present obesity, mild hirsutism, mild hypertension, and moderate glucose intolerance.

Although none is absolutely conclusive, several characteristics can more or less distinguish between transient functional hypercortisolism and true Cushing’s syndromewith secondary depression.

Classically in depression , the hypercortisolémic state is clinically and biologically mild. Urinary excretion of cortisol almost never exceeds three times the upper limit of normal.

The circadian pattern of plasma cortisol levels is less altered and sometimes a phase change phenomenon is simply observed.

The response of cortisol to insulin-induced hypoglycemia is present in depressed patients in contrast to patients with Cushing’s syndrome of any cause, including Cushing’s disease.

While the response of adrenocorticotropic hormone to corticotropin-releasing hormone is attenuated in contrast to the exaggerated response observed with Cushing’s disease. However, a wide overlap is observed.

However, the studies reveal few cases where it is not observed that patients have a specific cause for the state of depression.

In such cases, one may show few symptoms of depression, but it does not include any potential cause behind it. It is assumed that the person facing this type of condition suffers from an endogenous depression in medical terms.

Here the word endogenous clearly means “Coming from within” and this type of depression usually occurs due to few unwanted biochemical changes within the human body.

The professionals are still looking for possible reasons behind their unleashing. More generally, endogenous depression is classified as a mood-related disorder that may also be genetic in nature.

There are so many cases in which people are affected with this disorder from birth and have a lot of stress throughout their lives.

Research shows that this type of disorder is often not treated in young people or children; Most of the time people simply are not able to accept that they face some disorder until they begin to create some emotional and physical difficulties in their lives.

Professionals say that endogenous depression is often characterized by loss of interest in essential activities, poor sleeping postures and deterioration in concentration levels.

In earlier times, depression was cured by different practices; although this information may be useful only for researchers, but the fact is that in today’s world the treatment and diagnosis options have varied a lot.

Currently, depression is classified as an endogenous or reactive type. Keep in mind that reactive depression is one that arises from a certain situation or specific event in a person’s life.

It may be due to serious illness, grief, etc., but on the other hand, the term endogenous depression is related to patients who never show a positive response to treatment or medications and who do not even know what endogenous depression is.

Potential causes of endogenous depression

As already discussed, endogenous depression is a special type of genetic disorder that the person can develop by birth or early age due to few unwanted chemical changes within the brain.

Stress together with various traumatic circumstances often lead to situations in which the patient will not be able to get involved in particular life events.

Here it is important to know that the person affected with endogenous depression can belong to any age group and in most cases people can not identify their symptoms in the long term and does not receive treatment during the early stages of development. Symptoms associated with endogenous depression.

As there are no potential causes related to endogenous depression, here we will analyze the symptoms that can help you identify the disease in time to be able to choose the appropriate treatment.

Keep in mind that, the person suffering from endogenous depression often shows a similar type of symptoms as that of other patients with depression.

Generally, you may appear anxious, experience few changes in sleep patterns, show fatigue, face changes in normal eating habits and with sudden mood swings, you may also begin to lose self-confidence.

Studies reveal that the symptoms associated with endogenous depression often range from mild to severe, but it is not necessary for all patients to show similar symptoms.

Those who suffer from mental illness or have serious health concerns may face symptoms that vary in a wide range. In general, the symptoms related to endogenous depression are categories in four different sections as indicated below:

Impact on the patient’s physical well-being :

  • One can experience various problems of body pain.
  • It causes changes in sleep patterns.
  • One can face some difficulty while sleeping.
  • Endogenous depression is associated with prolonged fatigue.

Impact on feelings :

  • The person begins to have a sense of worthlessness.
  • It may show irritability over time.
  • Intolerable mood swings with the conditions of outburst of temper.
  • Great decrease in the level of motivation.
  • The person may feel tired all the time.

Impact on behavior :

  • You can find the affected person crying most of the time.
  • He / she will begin to move away from common social situations.
  • Decay in sexual desire.
  • In some cases, the person may also have less interest in personal preparation.
  • Start facing disinterest in most routine activities and even at work.

Impact on thought processing :

  • The person often has a thought of self-destruction and this is dangerous enough.
  • A feeling of self-pity
  • He / she often suffers with guilt.
  • Begin to develop a pessimistic attitude.
  • He often forgets things in the routine.
  • Decay in concentration levels.

In case you or someone in your family suffers any of these symptoms, then it is good to go to the endogenous depression clinic in May as soon as possible. Timely treatment can help you start a quick recovery.

As, there are so many symptoms associated with endogenous depression, so it is necessary to analyze them all with the doctor in order to implement the appropriate diagnosis that best suits individual needs.

Symptoms endogenous depression

The different types of mental disorders, which are caused by the influence of diurnal or seasonal mood changes, or these differences without any cause are referred to in medicine as endogenous depression.

Such disorders are a serious form of the disease, therefore, it is very important to take appropriate measures to prevent the development of a discomfort in order to exclude its progression.

The typical signs of the disease are thoughts about suicides, caused by low self-esteem. Particularly, very actively absorbed by such thoughts is the brain of a person in the morning, but it is not excluded at night.

A person with signs of this disease is prone to early awakenings and lack of nocturnal sleep. He perceives the surrounding world in a different way, not as a pessimist, but as an unnecessary creation, which leads him to a final idea of ​​suicide.

Believing that it is possible to be depressed without a cause is devastating

Some people say they are depressed for no reason because they can not find an event in their life that may have caused so much sadness and apathy. This is a very confusing situation for the person and his family, who do not know what is the cause of the depression.

In fact, in all disorders and diseases, understanding their origin helps us in some way to make sense of what is happening. Identifying and understanding the cause of depression gives us a greater sense of control because everything has a certain logic.

Not knowing why depressive symptoms manifest a profound sense of helplessness, we believe that we are at the mercy of circumstances and, therefore, we can not do much to combat depression.

However, one of the main mistakes we make is not knowing the difference between sadness and depression.

Sadness is a feeling that arises in response to any circumstance or thought, while depression is a disorder that includes sadness, but is also accompanied by other symptoms that generate a strong discomfort and the inability to continue with the activities of daily life .

This means that depression is not a reactive problem, so it is not always possible to find an environmental cause that justifies it.

Types of depression

There are two types of depression: reactive and circular (endogenous).

Reagent occurs in the case of unexpected stress : death of a loved one, a deadly disease, separation, etc.

Endogenous depression : it is an internal disease of a person. The provocation of the disease is due to the reduction of hormones, such as serotonin, dopamine and norepinephrine.

By underestimating their development, the person in the subconscious has ridiculous thoughts about its uselessness in this world, as well as a strong apathy, a sense of oppression and uselessness.

The most vulnerable people who are characterized by the manifestation of a disease are people with the following character traits:

  • Responsibility.
  • Integrity.
  • Anxiety.
  • Feeling the need to fulfill his duty.
  • Uncertainty.
  • Modesty.

Often people who have types of temperament become phalanges of the disease: phlegmatic and melancholic. Endogenous depression can occur unexpectedly, even in an episode of total well-being in the family.

It is often very difficult to determine the first signs of endogenous depression in a person, since, above all, this ailment is perfectly hidden behind the following factors:

  • Bad mood.
  • Sloth.
  • Fatigue.
  • Psychological problems.

Judging by this, it is worth noting that it is difficult for the layman to diagnose the disease “endogenous depression”.

Such symptoms of endogenous depression must necessarily alert the person and think about taking the appropriate measures to get rid of the ailment. Then, the symptoms of the disease are manifested by the following signs:

A person has periodic attacks of bad mood, which occur in a background not caused. These attacks may disappear, but after a short time they resume and appear even more.

Often, mood deterioration occurs in the spring or fall season. Depending on the saturation of the day, discomfort is characterized by activation in the morning and during the day. Towards night the symptoms diminished, but the nocturnal dreams already awaken a person of an ailment.

There is a slowness of body movements and mental activity. The patient is characterized by lack of attention, slower perception, the complexity of meditation. It is difficult for him to concentrate his attention on a certain goal, sometimes he does not hear and does not notice the people around him.

Afflicted with ailment you have symptoms of severe fatigue, even if you do nothing. Fatigue is based on the lack of will to perform any action.

The man himself (even without a good reason) is blamed for all sins, defects and defects. A feeling of pessimism accompanies him everywhere, even during sleep, which he spends anxiously.

The patient is characterized by a prolonged retirement to sleep, but after a few hours this dream is gone. For one person it is difficult to fall asleep, it turns around almost in the morning.

Often, the symptoms of a circular depression are reflected in a person’s appetite, or rather, in his absence. The patient eats little or nothing, which leads to weight loss, hungry fainting and the development of a digestive system, in particular, causes gastritis.

The physical pain itself is not felt by people, but he is worried about other pain symptoms. These pains include: melancholy, experience, intrusive thoughts about suicide, often the prolonged course of the disease causes twisted pains in the region of the joints, bones and muscles.

A person has self-esteem and complete self-confidence. Especially dangerous are these symptoms, if the patient lives alone and there is no one to support and calm him down.

Suicidal thoughts lead to attempts to interrupt life, but not to finish the job, because death is a complex and decisive step that people of weak spirit do not dare.

More symptoms of endogenous depression:

If you look at the image of the life of a person with this disease, then it is sad and empty. The patient lies in bed all day and does not want anything. The lack of desire does not lie in his laziness, but in the absence of any interest.

In the brain, the hormones of joy, love and pleasure do not occur, therefore, only suffering is peculiar to a person.

Suicidal thoughts in patients end in attempts, but in rare cases, the progression of this serious disease still overcomes fears and pushes death. It is very important that people with the disease of endogenous depression not be left alone with themselves.

Depressive people are inactive in dialogue, they are completely immersed in their experiences, sitting or reclining in a position. The people around have that feeling, as if a person had simply been disconnected from life.

He is not mentally ill, but the symptoms of the disease are in some way similar.

If the patient and speaks, the topic of conversation is only one: his depression, heaviness in the soul, uselessness, etc. The person in this state goes further and further away, which only leads to aggravate the disease. It is necessary to carry out medical measures as soon as possible.

Reasons for endogenous depression

The causes of the manifestations of endogenous depression are found in the lack of hormones produced, which were mentioned above. But what are the reasons for this phenomenon, consider it in more detail.

The main cause of the inadequate production of hormones, which affects the appearance of circular depressive illness, is a genetic predisposition. If the most distant generations even native had a peculiarity of manifestation of this disease, then the probability of depression in the offspring is high.

It is possible to beat a person who has weak character traits: distrust, indecision, anxiety. For those people, there is the fear of making any decision.

Sometimes, the drug does not exclude the cause of the disease through severe stress, although there is controversy about it. But to exclude the factors of a possible manifestation of the disease, it is worth protecting yourself from stressful situations.

Very often, it is women who are exposed to the manifestation of the ailment, which is associated with the biological characteristics of the structure of the psyche.

Diagnosis for endogenous depression

The discomfort of a person’s soul, in his opinion, is not the reason to seek medical help, and this is the main risk factor that affects the progression of the disease.

Many people consider that the state of depression is a normal phenomenon and believe that it will soon pass. These thoughts are wrong, because if you keep locking yourself in, it will be more difficult to get out of this state.

For this, it is necessary to carry out a survey of a person, by means of which a specialist doctor will be diagnosed. The diagnosis involves only examining the patient, talking to him, on the basis of which there is a detection of mental abnormalities.

Go see your family doctor or certified mental health professional. They can diagnose major depressive disorder.

  • You will be asked to provide a medical history.
  • Let them know about any medication you take.
  • Also provide information about any existing medical or mental condition.
  • Provide a family history of depression, if applicable.
  • Also inform them about any previous incidence of major depressive disorder, if applicable.

It will also answer questions about any symptoms you may experience. Tell them when the symptoms began. Also if they started after experiencing a stressful or traumatic event in their life.

The health care provider may also ask you to complete a questionnaire to examine how you feel. This will help determine if you have endogenous depression.

The key symptom to be diagnosed is: depressed mood or loss of interest or pleasure in daily activities for more than two weeks.

Like many diseases, endogenous depression is best treated in the early stages of the leak, so treatment should not be postponed.

Treatment options available

The treatment of endogenous depression is carried out by taking medications. In addition, psychotherapeutic advice can also be prescribed. This consultation is very important, because through such preventive measures, the person calms down and adopts the habitual habitual way of life.

It is possible to have the assistance of a professional medical expert regarding your mental health. To identify the symptoms and causes of depression, you will often be asked several questions related to your previous medical details.

It is essential to inform these professionals about all the changes you suffer in your mental health at different times and also provide details about medications if you are taking any of these for any specific health condition.

In addition, relatives should be informed about the diseases and possible treatments available in the world.

The health professional will try to know all the possible causes so that he can take advantage of the adequate medical health. You should also inform them if the symptoms are in the beginning stage or if they have increased after a certain traumatic event.

Some medical experts use it to perform a person’s test to get details about what they are facing at the current stage and what kind of mood these situations have developed for that person. Your answers will help you come to a good conclusion so that the later diagnosis can be made well.

It is not an easy task to recover a person from the condition of endogenous depression, but there are some options for special medications and therapy-based treatments that can help you get out of this problem.

If the treatment of the disease is carried out correctly, even in spite of the stage in which the progressive depression is found, the healing takes place quickly and without consequences.

Medications for endogenous depression:

Medical professionals have several options for the treatment of depression and anxiety, but in the case of endogenous depression, options are limited. In most cases, the person affected with endogenous depression must follow the prescription of serotonin reuptake inhibitors.

Few other options are norepinephrine, serotonin, and reuptake inhibitors. There are few medical experts who can recommend the use of tricyclic antidepressants, but in today’s world, they are rarely used.

These drugs extend their effectiveness to increase few specific hormonal productions in the human brain, so that the symptoms of depression can be reduced.

Some of the most commonly used drugs fall into the category of selective serotonin reuptake inhibitors and the list includes popular names such as citalopram, escitalopram, sertraline, fluoxetine and paroxetine, etc.

Keep in mind that many patients suffer few side effects with these medications, which include insomnia , nausea and headaches. But, all these problems will reach their normal state after a few days.

The serotonin and norepinephrine reuptake inhibitors are another option, and the list includes drugs such as dexafaxine, duloxetine, and salefaxine, etc.

There are few cases in which physicians prefer to use treatment methods based on tricyclic antidepressants such as nortriptyline , imipramine and trimipramine, etc.

But studies reveal that the side effects associated with the tricyclic antidepressant are more dangerous compared to all other antidepressants available in the market. In most cases, the tricyclic antidepressant causes weight gain, dizziness and the person may also suffer from drowsiness.

In case you experience any of these symptoms while using these medications, then you need to go to the doctor and find the right solution for it. The person needs to consume these medications for at least 4 to 6 weeks and the expert will continue to notice an improvement in symptoms.

In some critical cases, medication-based treatment can take up to 12 weeks to take advantage of adequate improvement.

In case you can not find any benefit of certain recommended medications, it is essential to consult your doctor on time and replace them with a different prescription.

Studies reveal that there are very few possibilities of observing positive changes immediately after the initial doses of drugs for patients with endogenous depression. In most cases of treatment, one may need combination treatments to obtain better results.

Even if the symptoms of this state of depression begin to improve with few weeks of prescription medication, it is essential to carry out the same routines for longer. One should stop medications only after the doctor’s recommendation.

Most medical experts follow a gradual deterioration in the doses of the drugs instead of stopping them altogether.

Therapy for endogenous depression:

The treatment is performed by a psychotherapist or psychiatrist in a hospital and includes:

A competent choice of method of curing antidepressants. Antidepressants affect the increase in the production of hormones in the brain.

Medications should be taken for several months or even years until they are fully recovered.

To increase the effectiveness of the treatment, it is not excluded that tranquilizers, stimulants, nootropics and sedatives are prescribed to the patient.

Another option for the treatment of endogenous depression is psychotherapy which is also known as talk therapy. In this case, the patient needs to meet with experts on a routine basis.

This therapy is sufficiently useful for the treatment of cases of endogenous depression. There are also two options under this category: the first is known as Interpersonal Therapy and the second option is Cognitive Behavioral Therapy .

Keep in mind that the second on the list can help the person affected with endogenous depression to replace most of the negative thoughts with the positive ones.

In this case, one needs to practice positive thinking and limit the movement of negative thoughts in mind. Slowly begin to improve the ability of the person to respond to positive situations in a better way, while discarding the negativities of life.

In another case, if you are having relationship-related problems, you may need to undergo interpersonal therapy. Doctors may also prefer to use the combination of both treatments in some cases.

Changes in lifestyle:

If you need to get out of the unwanted state of life of depression, then few positive changes in lifestyle are essential for man. It should start with a positive change in routine activities that can help improve the symptoms of endogenous depression.

At the initial level, your body will not find these activities or appropriate changes, but over time it will begin to adapt to the differences and then the mind and body will begin to recover over time.

You can try these things to get positive results as soon as possible:

  • Try to improve your diet and switch to a healthy diet that includes vegetables, lean proteins and whole grains.
  • Sleep at least 6 hours per night.
  • You can try writing new magazines or books with your own creative thoughts.
  • Go out with your family, friends and relatives to have fun and create happy memories for life.
  • Try to get involved in activities that you often use to love before falling into this state of depression .
  • Go on adventure sports such as cycling or hiking, etc.

One can quickly recover from problems of endogenous depression if the right treatment is adjusted at the right time.

It is important to stay in regular contact with your mental health expert and follow his suggestions to get rid of all the health problems in your life.

Differences between endogenous depression and major depression

While there is considerable overlap in the way these types of symptoms have been characterized, endogenous depression is a type of depression that apparently occurs without any reason.

It seems to be chemical and / or genetic. It is often accompanied by feelings of guilt, uselessness and inability to enjoy normally pleasurable things.

Exogenous or reactive depression, on the other hand, is usually triggered by some type of external stressor, such as the loss of a loved one, divorce, loss of a job or difficulties in the relationship.

While in endogenous depression the world may seem a dark and sad place because of you, yourself, you are dark and sad inside, in exogenous depression, the world seems dark and sad because of what is happening in your life.

In addition, exogenous depression tends to be characterized by a lack of certain physical symptoms, such as problems with sleep and appetite.

Whether depression is endogenous or exogenous, it is almost always triggered by some stressful factor in life. This means that if a person has a genetic and / or biochemical predisposition to depression, a major life stressor can push that tendency toward existence.

As for how depression is currently treated, it does not seem to make a difference what type of depression a person has. Studies conducted in the eighties and nineties were not able to establish any kind of link between the type of depression that a person manifested and how well the antidepressants alleviated their symptoms.

However, ideas may change in the future. A 2012 study found that there is evidence of different pathways in the brain that are responsible for these two types of depression.

While the results are still very preliminary, it could mean that these two types of depression could be attacked in different ways in the future.

What is the difference between endogenous depression and exogenous depression?

In the 1980s, two types of depression were usually mentioned: endogenous depression and exogenous depression. The main difference was in the cause of the disorder.

Endogenous depression occurs without the occurrence of stress or trauma. It is usually caused by a genetic and / or biological factor. It is sometimes called “biological base” depression. For internal factors, from neurochemical imbalance to negative thought patterns.

Conversely, exogenous depression, also known as reactive depression, one can find the trigger in the person’s life, is experienced after someone experiences a stressful or traumatic event, such as a death in the family, a divorce or a trauma like an accident.

This type of depression is called reactive depression. But this separation is not very useful to understand the causes of depression, since in one way or another in the emergence and consolidation of this disorder, internal and external factors always intervene.

Depression is a multicausal disorder, which means that it affects the characteristics of the person, as well as the resources to cope with the person, the biochemistry of the brain and stressful events.

This means that although some people think they are depressed for no apparent reason, the fact is that they do not know the cause and can not identify the stressful event.

Mental health workers no longer differentiate these two types of major depressive disorders. A diagnosis now is simply: major depressive disorder.