Mobicox: Uses, Administration, Side Effects, Precautions, Warnings and Interactions

It belongs to the family of drugs known as COX-2 that inhibit non-steroidal anti-inflammatory drugs (NSAIDs).

It is used to treat rheumatoid arthritis and painful osteoarthritis in adults. It helps with these conditions by relieving pain and reducing swelling and inflammation .

NSAIDs work by blocking a response to an injury in the body that causes inflammation and pain.

This drug can be available under multiple brand names and / or in different forms.

Any specific brand of this drug may not be available on all forms or approved for all conditions discussed here. Also, some forms of this drug cannot be used for all of the conditions discussed here.

Your doctor may have suggested this drug for conditions other than those listed in these drug information articles.

If you have not discussed this with your doctor or you are not sure why you are taking this medicine, talk to your doctor. Do not stop taking this medicine without consulting your doctor.

Do not give this medicine to anyone else, even if they have the same symptoms as you. It can be harmful for people to take this medicine if their doctor has not prescribed it.

What form (s) is this medicine in?

7,5 mg

Each round, pastel yellow tablet, marked with ‘M’ on one side and the company (Boehringer) logo on the other side, contains 7.5 mg of Mobicox.

Non-medicinal Ingredients:  Anhydrous Colloidal Silica, Crospolyvidone, Lactose, Magnesium Stearate, Microcrystalline Cellulose, Polyvidone, and Sodium Citrate.

15 mg

Each round, pastel yellow, snap-tab tablet, marked “77C” on both sides of a broad line on its curved side and the company (Boehringer) logo on its rounded side, contains 15 mg of Mobicox.

Non-medicinal Ingredients:  Anhydrous Colloidal Silica, Crospolyvidone, Lactose, Magnesium Stearate, Microcrystalline Cellulose, Polyvidone, and Sodium Citrate.

How should I use this medicine?

Rheumatoid arthritis: The usual starting dose of Mobicox to treat the symptoms of rheumatoid arthritis is 15 mg once a day. For some people who may respond well to medication, your doctor may reduce the dose to 7.5 mg once a day, as needed.

Osteoarthritis : The recommended dose for osteoarthritis pain relief is 7.5 mg once a day. The doctor can increase this to 15 mg taken once a day if necessary.

For both conditions, the maximum dose of Mobicox is 15 mg once a day. This medicine can be taken with or without food.

Use of this medicine should be limited to the lowest effective dose for the shortest period of time needed.

Many things can affect the dose of medicine a person needs, such as body weight, other medical conditions, and other medicines.

If your doctor has recommended a different dose than those listed here, do not change the way you are taking the medicine without consulting your doctor.

It is important that you take this medicine exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for the one you forgot.

If you are not sure what to do after you miss a dose, contact your doctor or pharmacist.

Store this medicine at room temperature, protect from light and moisture, and keep out of the reach of children.

Do not dispose of medicines in sewage (for example, in the sink or toilet) or household waste. Ask your pharmacist how to dispose of medicines that are no longer needed or that have not expired.

Who should NOT take this medicine?

Do not take this medicine if:

  • You are allergic to Mobicox or any ingredient in the medication.
  • You are about to have or have recently had coronary artery bypass graft (CABG) surgery.
  • You are pregnant or breastfeeding.
  • You are under 18 years of age.
  • You have active or recent stomach or intestinal ulcers or bleeding.
  • You have bleeding from the brain or other bleeding disorders.
  • You have experienced asthma , hives, nasal polyps, or allergic reactions after taking ASA or other NSAIDs.
  • You have higher than normal potassium levels in your blood.
  • You have inflammatory bowel disease ( Crohn’s disease or ulcerative colitis).
  • It has severely reduced kidney function or worsened kidney function.
  • You have severely reduced liver function or active liver disease.
  • You have severe uncontrolled heart failure.

What side effects are possible with this drug?

Many medications can cause side effects. A side effect is an unwanted response to a drug when taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by all people taking this drug. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of the people taking this medicine. Many of these side effects can be controlled, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist can advise you on managing side effects.

  • Constipation .
  • Diarrhea .
  • Drowsiness.
  • Gas / flatulence.
  • Headache.
  • Indigestion.
  • Ulcers in the mouth.
  • Sickness.
  • Sensitivity to sunlight.
  • Pain in the mouth
  • Uncomfortable feeling in the stomach.
  • Weight changes

Although most of these side effects listed below don’t happen very often, they could lead to serious problems if you don’t seek medical attention.

Check with your doctor as soon as possible if you experience any of the following side effects:

  • Blurry vision.
  • Confusion.
  • Fever.
  • High blood pressure
  • Painful urination or difficulty urinating.
  • Pounding of the heartbeat.
  • Ringing in the ears.
  • Swelling of the feet or lower legs.
  • Signs of anemia (low levels of red blood cells, eg dizziness, pale skin, unusual tiredness or weakness, shortness of breath).
  • Signs of clotting problems (for example, unusual nosebleeds, bruising, blood in urine, coughing up blood, bleeding gums, cuts that won’t stop bleeding).
  • Signs of depression (for example, poor concentration, weight changes, sleep changes, decreased interest in activities, thoughts of suicide).
  • Signs of infection (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness).
  • Signs of kidney problems (eg, increased urination at night, decreased urine output, blood in the urine, painful urination, or difficulty urinating).
  • Signs of liver damage (eg, yellow skin or eyes, abdominal pain, dark urine, clay-colored stools, loss of appetite, nausea and vomiting, or itching).
  • Skin rash or itching
  • Small, red spots on the skin.
  • Swelling of the lower legs, ankles, or feet.
  • Unexplained weight gain
  • Persistent vomiting or nausea, indigestion, stomach pain, or diarrhea.

Stop taking the medicine and seek immediate medical attention if any of the following occur:

  • changes in the amount or color of your urine (such as red or brown urine)
  • Fainting.
  • Seizures
  • Severe stomach pain
  • Difficulty breathing.
  • Signs of stomach bleeding (for example, bloody, black, or tarry stools, spitting up blood, vomiting blood, or material that looks like coffee grounds).
  • Signs of breathing problems (eg, shortness of breath, shortness of breath, wheezing or tightness in the chest, rapid or irregular breathing).
  • Signs of meningitis not caused by infection (eg, headache (severe), throbbing, or stiff neck or back).
  • Signs of a severe allergic reaction (eg, hives, difficulty breathing, swelling of the face, mouth, throat, or tongue).
  • Signs of a severe skin reaction (for example, blistering, peeling, a rash covering a large area of ​​the body, a rash that spreads quickly, or a rash combined with fever or malaise).

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptoms that concern you while taking this medicine.

Are there any other precautions or warnings for this drug?

Before you start using a medication, be sure to tell your doctor about any medical conditions or allergies you may have, any medications you are taking, if you are pregnant or breastfeeding, and any other important information about your health.

These factors can affect the way you should use this medicine.


People taking this drug should not drink alcohol, as this can increase the risk of stomach problems with the drug.

Allergic reactions

If you have had a reaction to acetylsalicylic acid (ASA) or other NSAIDs (eg, ibuprofen, ketoprofen, diclofenac) including runny nose, itchy skin rash, nasal polyps, or shortness of breath and wheezing, you should not take this medicine.

If you experience symptoms of a severe allergic reaction (eg, hives, difficulty breathing, wheezing, swelling of the face, tongue, or throat), get medical attention immediately.

Bladder symptoms

This medicine can cause bladder symptoms, such as frequent or painful urination and blood in the urine. If you develop these symptoms, stop taking this medicine and contact your doctor immediately.

Blood pressure

Like other NSAIDs, Mobicox can cause increased blood pressure, which can contribute to other heart conditions.

If you have high blood pressure, talk with your doctor about how this drug may affect your medical condition, how your medical condition may affect the dosage and effectiveness of this drug, and if any special monitoring is needed.

Drowsiness / reduced alertness

Mobicox may reduce the mental or physical abilities required to perform dangerous tasks, such as operating machinery or driving a motor vehicle.

Avoid these and other dangerous tasks until you are sure this drug does not affect your ability to do so safely.


Fertility may decrease in people taking this drug. This medicine is not recommended for women who are trying to get pregnant.

Heart attack and stroke

The use of COX-2 NSAIDs, including Mobicox, is associated with an increased risk of heart attack and stroke. This risk increases with higher total daily doses and taking the drug for long periods of time.

If you have a history of heart disease, including heart attack and stroke, talk to your doctor about the benefits and risks of taking this drug. Ask your doctor about all the available treatment options that may be right for you.

Heart conditions

This drug can cause fluid retention, which will make symptoms of certain heart conditions worse.

If you have heart failure, high blood pressure, or other medical conditions that increase your risk of fluid retention (for example, kidney problems), talk to your doctor about how this drug may affect your medical condition, how your medical condition may affect dosage. and effectiveness of this drug.


This medicine can mask signs of infection such as fever or muscle aches. If you notice other symptoms of infection (eg painful or frequent urination, sore throat, cough), contact your doctor.

Inform health professionals

Be sure to tell any healthcare professional (including your doctor, nurse, pharmacist, and dentist) involved in your care that you are taking this medicine, especially if you have heart surgery scheduled.

Renal function

This medicine can affect kidney function. You are at higher risk of developing kidney problems if you are an older adult, take diuretics (eg, hydrochlorothiazide, furosemide), or already have kidney disease or heart failure.

Your doctor can monitor your kidney function with blood tests when you are taking this medicine. Mobicox is not recommended for people with severe kidney failure if they are not on dialysis.

Liver function

This medicine can affect your liver function or cause liver problems. If you experience symptoms of liver problems (eg, nausea, vomiting, feeling tired, yellowing of the skin or eyes), contact your doctor immediately.

If you have liver problems, talk to your doctor about how this drug may affect your medical condition, how your medical condition may affect the dosage and effectiveness of this drug, and if any special monitoring is needed.

People with severely reduced liver function or active liver disease should not take this drug.

Potassium levels

Mobicox can cause high levels of potassium in the blood.

You are at greater risk of high potassium levels in your blood if you are an older adult, have diabetes or kidney failure, or are taking beta-blockers (eg, Metoprolol, atenolol), angiotensin converting enzyme (ACE) inhibitors (e.g. Eg, Ramipril, enalapril), or some diuretics (eg, triamterene, amiloride).

Because extremely high levels of potassium in the blood can contribute to other conditions, such as heart problems, your doctor will monitor your potassium level with blood tests while you are taking this drug.

Ulcers and bleeding in the stomach and intestines

This medicine can cause stomach ulcers and stomach bleeding. These complications can occur at any time and are sometimes severe.

If you have had a stomach or intestinal ulcer, diverticulosis, Crohn’s disease, or ulcerative colitis, talk with your doctor about how this medication may affect your medical condition, how your medical condition may affect the dosage and effectiveness of this medication, and whether it exists. some special control is necessary.

If you experience symptoms of an ulcer or other stomach problems (for example, stomach or abdominal pain, black stools, vomiting similar to blood or coffee flu, weakness), contact your doctor immediately or seek medical attention immediately.


This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medicine, contact your doctor immediately.

It should not be used during the last 3 months of pregnancy as it can cause heart and kidney problems for the developing baby and cause prolonged labor with excessive bleeding during delivery.


Many anti-inflammatory drugs are known to pass into breast milk. If you are a nursing mother and you are taking Mobicox, it may affect your baby. Breastfeeding while taking Mobicox is not recommended.

Children:  The safety and efficacy of using this medicine have not been established for children.

Seniors: Seniors may be at increased risk for side effects and should be closely monitored by their doctors while taking this drug.

What other drugs could interact with this medicine?

There may be an interaction between Mobicox and any of the following:

  • Acetylsalicylic acid (ASA).
  • Aliskiren.
  • Alteplase.
  • Aminoglycoside antibiotics (eg, amikacin, gentamicin, tobramycin).
  • Amiodarone
  • Angiotensin converting enzyme (ACE) inhibitors (eg, ramipril, enalapril, captopril, quinapril).
  • Angiotensin receptor blockers (ARBs, eg candasartan, irbesartan, losartan).
  • Apixabán.
  • Aprepitant.
  • Antifúngicos «azoles» (p. ej., itraconazol, ketoconazol, voriconazol).
  • Bloqueadores beta-adrenérgicos (p. ej., atenolol, propranolol, sotalol).
  • Bimatoprost.
  • Bisphosphonates (e.g., alendronate, ethidronate).
  • Bosentan.
  • Carbamazepine.
  • Celecoxib.
  • Cholestyramine.
  • Cilostazol.
  • Clopidogrel.
  • Colestipol.
  • Cyclosporine.
  • Dabigatran.
  • Dabrafenib.
  • Dasatinib.
  • Deferasirox.
  • Delaviridina.
  • Desmopressin
  • Desvenlafaxine.
  • Digoxin.
  • Dipyridamol.
  • Diuretics (water pills, eg, furosemide, hydrochlorothiazide, triamterene).
  • Eplerenona.
  • Fenofibrate.
  • Fluvastatina.
  • Gemfibrozil.
  • Glucosamine
  • Haloperidol.
  • Heparin.
  • Herbal products that affect blood clotting (eg, cat’s claw, chamomile, evening primrose, feverfew, fenugreek, garlic, ginger, ginseng, turmeric).
  • HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs, eg, Delaviridine, efavirenz, etravirine, nevirapine).
  • Hydralazine.
  • Ibrutinib.
  • Latanoprost.
  • Lithium.
  • Low molecular weight heparins (eg, dalteparin, enoxaparin, tinzaparin).
  • mesalamine.
  • Methotrexate
  • Mifepristona.
  • Milk thistle
  • Multivitamins (with vitamins A, E) with or without minerals.
  • Nilotinib.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs, e.g., diclofenac, ibuprofen, naproxen).
  • Omega-3 fatty acids.
  • Omeprazol.
  • Oral corticosteroids (eg, dexamethasone, hydrocortisone, prednisone).
  • Pemetrexed.
  • Pentoxifilina.
  • Phenobarbital.
  • Phenytoin
  • Primidona.
  • Probenecid.
  • Quinolone antibiotics (eg, ciprofloxacin, norfloxacin, ofloxacin).
  • Rifampin.
  • Rivaroxaban.
  • Selective serotonin reuptake inhibitors (SSRIs, eg, citalopram, duloxetine, fluoxetine, paroxetine, sertraline).
  • Serotonin / norepinephrine reuptake inhibitors (SNRIs, eg, desvenlafaxine, duloxetine, venlafaxine).
  • Sodium phosphates.
  • Sulfasalazina.
  • Antibióticos sulfonamida («sulfas»; p. ej., sulfisoxazol, sulfametoxazol).
  • Tacrolimus.
  • Tenofovir.
  • Ticagrelor.
  • Ticlopidina.
  • Tipranavir.
  • Tolbutamida.
  • Antidepresivos tricíclicos (p. ej., amitriptilina, clomipramina, desipramina, trimipramina).
  • Trimethoprim.
  • Urokinase.
  • Vancomycin.
  • Venlafaxine.
  • Vitamin E.
  • Warfarin
  • Zafirlukast.

If you are taking any of these medications, talk to your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • Stop taking one of the medications.
  • Change one of the medications to another.
  • Change the way you are taking one or both medicines.
  • Leave everything as is.

An interaction between two drugs does not always mean that you should stop taking one of them. Talk to your doctor about how drug interactions are managed or should be controlled.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription and non-prescription (non-prescription) medications you are taking.

Also tell them about any supplements you’re taking. Because caffeine, alcohol, nicotine from cigarettes, or illegal drugs can affect how many medications work, you should tell your doctor if you use them.