Genoprazole: Formula, Indications, Mechanism of Action, Dosage, Warnings, Contraindications and Interactions

It is a drug whose active principle is omeprazole. Omeprazole is a gastric protector that decreases the amount of acid produced in the stomach.

Genoprazole chemical formula

  • C17H19N3O3S.


The presentation for marketing is in capsules of 20 mg.

Indications of genoprazole

It is used to treat several stomach-related conditions caused by excess acids, such as indigestion and ulcers.

With pantoprazole, you can prevent the formation of ulcers or help the healing process where damage has already occurred.

Genoprazole may be given along with antibiotics to treat Helicobacter pylori, a bacteria found in the stomach that can cause ulcers.

Genoprazole can prevent ulcers caused by medications such as non-steroidal anti-inflammatory drugs such as diclofenac, ibuprofen, and naproxen, among others.

It is also used in diseases like gastroesophageal reflux, acid refluxhiatus hernias, acidity, and generally to support digestive health .


Mechanism of action

Genoprazole inhibits the activity of the acid (proton) pump, H + and K + adenosine triphosphatase (ATPase), which is found on the secretory surface of the gastric parietal cell.

This blocks gastric acid formation and relieves symptoms, allowing healing to occur.

However, this blockage does not prevent food from being digested in the usual way.

The recommended dose of pantoprazole

For active duodenal ulcer

In adults: 20 mg orally, daily, for 4 to 8 weeks.

Helicobacter pylori eradication to reduce the risk of duodenal ulcer recurrence

20 to 40 mg of pantoprazole in adults is recommended with clarithromycin and amoxicillin treatment for ten days.

For patients with an ulcer present when therapy begins, an additional 18 days of genoprazole 20 mg once daily is recommended for ulcer healing and symptom relief only.

Severe erosive esophagitis, symptomatic gastroesophageal reflux disease, insensitive

20 mg orally daily for 4 to 12 weeks is recommended in adults. Patients with symptomatic gastroesophageal reflux disease can continue with a maintenance dose of 20 mg per day for up to 1 year.

Hypersecretory pathological conditions (such as Zollinger-Ellison syndrome)

In adults, the recommended starting dose is 60 mg orally daily. Amounts should be adjusted based on the patient’s response. Therapy should be continued for as long as clinically indicated.

Gastric ulcer

40 mg orally, daily for 4 to 8 weeks in adults is recommended.

Patients with hepatic impairment may need dose adjustments.

Side effects:

  • Headache, dizziness, asthenia.
  • The feeling of irritability and changes in heart rate
  • Loose stools ( mild diarrhea ), abdominal pain, nausea, vomiting, constipation, flatulence, bloating, gas, and general upset stomach.
  • Back pain, signs of low magnesium levels, such as muscle cramps, weakness, and tiredness.
  • Cough, upper respiratory infection, cold symptoms such as stuffy nose, sneezing, sore throat.
  • Signs of an allergic reaction such as rash, fever, and painful joints.
  • Worsening of stomach problems such as bad stomach pain, blood in the stools or black stools, blood vomit, or dark-colored vomit.

Warnings and Contraindications

  • Genoprazole should not be given during pregnancy or if you plan to become pregnant.
  • Genoprazole can affect the unborn baby if it is administered during pregnancy.
  • Your doctor will discuss the risks and benefits of taking pantoprazole during pregnancy.
  • It is unknown whether the drug passes into breast milk, so the patient should avoid breastfeeding during treatment.
  • Its administration in pediatric patients is not recommended since safety in children has not yet been established.
  • Genoprazole is contraindicated in hypersensitive patients to the drug or its components.

Genoprazole interactions

This drug alters the bioavailability of any drug; the absorption depends on the pH (ketoconazole, iron salts, among others).

This drug relatively increases the concentration of clarithromycin in the blood and can increase the leukopenic and thrombocytopenic effects of hematopoietic depressant drugs.

The substance for intravenous infusion is compatible only with saline and dextrose (the use of other solvents may decrease the stability of pantoprazole due to changes in the pH of the infusion medium).

Avoid everyday use of ampicillin esters, iron derivatives, itraconazole, and ketoconazole, as they cause poor bioavailability because optimal absorption of these drugs requires a low gastric pH.

The patient should be closely monitored to reduce the effect or toxicity when co-administered with diazepam, phenytoin, propranolol, theophylline, and warfarin because it can impair the results of these drugs.

Because pantoprazole slows down the elimination of drugs metabolized in the liver by microsomal oxidation (such as warfarin, diazepam, and phenytoin, among others).

The doctor should be informed of the use of Clopidogrel, antiviral medicines such as atazanavir and nelfinavir, used to treat infections such as HIV or tacrolimus, an immunosuppressive drug, used to aid in organ transplants.

Genoprazole can interact with some medications and herbal supplements.

In the male fern case, it is inactivated in alkaline environments. The Pennyroyal can change the rate at which the toxic metabolites of Pennyroyal are formed. Therefore joint use should be discouraged.