Ebastel: Formula, Dosage, Mechanism of Action, Indications, Side Effects and Interactions

This medication is indicated to treat relief of symptoms that occur in allergic processes, and its composition is ebastine.

Easter is a drug belonging to the antihistamines group, commonly called antiallergics.

Ebastine blocks potently, reversibly, and specifically to H1 receptors, reducing the systemic effects of histamine.

It diminishes the symptoms associated with allergic processes such as eye redness or nasal congestion. It also produces a bronchodilator effect and a decrease in dermal pruritus.

Ebastine lacks significant sedative effects.

It shows excellent selectivity for H1 receptors.

Chemical formula

  • C32H39NO2.
  • 4-(4-benzhydryloxy-1-piperidyl)-1-(4-tert-butylphenyl)butan-1-one.


The dose of ebastel in adults and children over 12 years is one tablet of 10 mg of ebastine once a day.


Moreover, in the case of patients with severe liver diseases, the maximum dose can not exceed 10 mg of ebastine per day.

Mechanism of action

The ebastel inhibited quickly and prolonged the effects induced by histamine, a compound that acts in the body as a hormone and neurotransmitter. It also has a fundamental role in allergic reactions and the immune system.

The ebastel has a strong affinity for histamine receptors, type H1.


The ebastel is indicated in the case of allergic processes and alleviates symptoms such as perennial or seasonal allergic rhinitis that may or may not be associated with allergic conjunctivitides, such as:

  • The nasal drip
  • The itching in the nose.
  • The itchy eyes.
  • The tearing.
  • The desire to sneeze.
  • Chronic urticaria.
  • Allergic dermatitis.

Side effects

The following side effects have been reported in patients with Ebastel treatments and are classified by their level of occurrence:

Very frequent

Those that affect more than 1 in 10 patients.

  • Headaches.


Those that affect 1 in 10 patients.

  • Somnolences
  • Dry mouth.


Those that affect 1 in every 1,000 patients.

  • Hypersensitivity As are allergic reactions such as angioedema and anaphylaxis.
  • Nervousness and insomnia.
  • Dizziness decreased sensitivity and sensation of touch, alteration or diminution of the sense of taste.
  • Palpitations and tachycardia.
  • Abdominal pain, vomiting, nausea, and some digestive problems.
  • Inflammation of the liver, cholestasis, hepatitis, abnormal liver function tests.
  • Urticaria, rashes, and dermatitis.
  • Disorders in menstruation.
  • Edema or swelling due to fluid accumulation and fatigue.


Contradictions in the use of Easter are associated with the allergy to ebastine or any of the medication components.

Warnings and precautions

Easter should be used with caution in the following cases:

  • If the electrocardiogram results are altered as prolongation of the QT interval.
  • If you have high levels of potassium in the bloodstream.
  • If you have severe liver disease.
  • It should not be used during lactation.
  • If you have lactose intolerance.
  • During medication administration, you must avoid carrying out work that involves special coordination and mental alertness, such as handling vehicles or machinery.
  • Ingestion of central nervous system depressants such as alcohol or drugs increases the risk of accidents.


Among the medications that can interfere with the effects of Easter can be mentioned:

  • They can alter the electrocardiogram: ketoconazole and itraconazole are used to treat infections caused by fungi or antibiotics.
  • Erythromycin used to treat certain infections can cause alterations.
  • It may increase the effect of other medications used to treat allergies (antihistamines).
  • The antihistamine effect of Easter may be diminished in patients treated with rifampicin (tuberculosis).
  • Interferences with diagnostic tests. Easter can interfere with the results of skin allergy diagnostic tests, so it is advisable not to do so until after five to seven days have elapsed from the time of treatment interruption.


In case of overdose or accidental drug ingestion, you should immediately consult the doctor and go to the nearest hospital.

The treatment for poisoning by this medication consists of gastric lavage and administering the appropriate medication.

Do not administer a double dose of ebastel to compensate for forgotten doses.