Demyelinating Diseases: What are they? Symptoms, Types and Treatment

Demyelination occurs when the protective layer of nerve cells, known as myelin, is damaged.

When this happens, neurological problems may occur.

Demyelinating diseases damage the linings of nerve cells.

Many of the nerve fibers in the nervous system are covered with a white, fatty substance called myelin. These myelin sheaths allow electrical impulses to be transmitted along nerve cells quickly and efficiently.

How well these impulses are conducted determines how smoothly and quickly a person can perform daily movements with little conscious effort.

Some diseases cause damage to these protective myelin sheaths, which can cause problems in the brain , eyes and spinal cord . These conditions are known as “demyelinating diseases.”

Symptoms of demyelinating diseases

In general, demyelinating diseases can affect:

  • View.
  • Reflections and movement.
  • The senses.
  • Mood.

People who experience any of these symptoms may also experience persistent exhaustion that does not seem to have a particular cause.

Visual symptoms:

People with a demyelinating disease may experience blurred vision, loss of vision, double vision or may feel their vision swing back and forth.

Motor symptoms:

Some people may also experience weakness in their extremities and trunk of their body, or have trouble balancing. In addition, muscles can contract, causing stiffness or tightness and interfering with movement and speech.

People may also experience spikes in blood pressure and rapid heartbeat due to a nervous system that overreacts.

Sensory symptoms:

Some people may experience sensations of numbness, burning or tingling in their arms, legs or feet. They may also feel pain when touched lightly.

Some people with a demyelinating disease, such as multiple sclerosis (MS), get a symptom called Lhermitte’s sign. This feels like an electric shock that goes through the back of the neck to the spine and then through the arms and legs.

Symptoms related to the brain:

Demyelinating diseases can cause memory problems, difficulty concentrating and cognition problems.

People with a demyelinating disease may also experience tremor or incoordination. Sometimes, actions such as swallowing, writing, eating and walking can be difficult.

Memory, concentration, attention and processing speed can be affected by demyelinating diseases. People commonly experience depression , anxiety and irritability.

Symptoms that affect the genitourinary system:

Demyelinating diseases can affect the frequency with which someone needs to use the bathroom. These conditions can cause people to have incontinence (where they can not control their bladder or bowels) or constipation (where they can not empty their bowels regularly and completely).

Urinary tract infections may also be more common in people with demyelinating diseases.

The sexual health of people with demyelinating diseases can be affected. Men may be unable to have an erection, and both women and men may be unable to achieve orgasm. People with demyelinating diseases can also experience pain during sex.

Types

There are many different types of demyelinating diseases. The diagnosis varies from one disorder to another.

The term multiple sclerosis means “many scars.” It refers to areas of the brain and spinal cord where myelin has been lost , leaving hardened scars that may appear at different times and in different places.

Unfortunately, there is currently no cure for MS, but many of the symptoms can be treated.

There are medications available to treat MS relapses and control symptoms, which are usually taken orally or by injection.

MS is more common among women than among men. In fact, approximately three women and two men suffer from this particular demyelinating disease.

Although MS is not hereditary, some doctors believe that genes can make some people more susceptible to the disease than others.

Optic neuritis:

Optic neuritis is another type of demyelinating disease that can arise from multiple sclerosis.

This condition is more common among people between 20 and 40 years old. Its most common symptoms are pain with eye movement, loss of vision or loss of vision of colors.

Optic neuritis is often treated with corticosteroids , although if doctors suspect that MS is causing the problem, they can prescribe medication for MS.

Optic neuromyelitis:

Optic neuromyelitis, or Devic’s disease, occurs when the immune system attacks and destroys myelin, causing pain in the spine and extremities and causing problems in the bladder and bowel.

Optic neuromyelitis can sometimes cause death if a person’s breathing is affected. It is likely that the initial attack of optic neuromyelitis is treated with corticosteroids. Medicines that suppress the immune system, called immunosuppressants , can be used to prevent further attacks.

Mielitis beam;

Transverse myelitis is an inflammation of the spinal cord . This type of demyelinating disease affects sensitivity and can cause pain and weakness in the arms and legs, as well as causing problems in the bladder and bowel. About 1,400 new cases of transverse myelitis are diagnosed each year in the United States.

Similar to other demyelinating diseases, corticosteroids can be prescribed to reduce inflammation of the spine.

For people who do not respond to corticosteroids, doctors may recommend plasma exchange therapy. This procedure involves replacing the plasma (the fluid in which blood cells and antibodies travel) with special fluids.

Analgesics such as acetaminophen, ibuprofen, and naproxen may also help with muscle pain.

Acute disseminated encephalomyelitis:

Acute disseminated encephalomyelitis (ADEM) is a widespread attack of inflammation in the brain and spinal cord. Inflammation damages myelin and can cause fever, exhaustion, headache, nausea and vomiting.

In some severe cases, people may experience seizures, go into a coma or die. A small fraction of people with this condition develop MS.

Like transverse myelitis, corticosteroids or plasma exchange therapy can be considered to reduce inflammation caused by ADEM.

Adrenoleukodystrophy and adrenomyeloneuropathy:

Adrenoleukodystrophy and adrenomyeloneuropathy are inherited and rare demyelinating diseases that are caused by a genetic mutation that usually only affects men. However, some women may carry the gene and, in some cases, women may develop symptoms.

The symptoms of these conditions vary and cover the full range of symptoms of demyelinating disease described above.

If people with adrenoleukodystrophy or adrenomyeloneuropathy have low levels of adrenaline and cortisol, then a doctor can prescribe steroids, which can replace hormones and improve a person’s quality of life.

Other treatments for these conditions are currently in clinical trials.

Treatment

Currently there are no cures available for demyelinating diseases. As a result, treatment tends to focus on reducing and managing symptoms, as well as slowing the progression of the disease.

When demyelination occurs, new myelin can grow. However, the new myelin is not as strong and protective as the old myelin, which means that the transmission of electrical impulses is not as efficient as before.

Researchers are studying what can be done to improve the way the body produces new myelin.

For now, people with demyelinating diseases should make sure to talk with their doctor about their treatment options.